{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:00:38Z","timestamp":1790085638313,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate intestinal injury, repair and vasculitis biomarkers that may illuminate the progression and\/or pathogenesis of feline infectious peritonitis (FIP) or feline enteric coronavirus (FECV) infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A total of 40 cats with effusive FIP (30 with abdominal effusion, AE group; 10 with thoracic effusion, TE group) and 10 asymptomatic but FECV positive cats (FECV group), all were confirmed by reverse transcription polymerase chain reaction either in faeces or effusion samples. Physical examinations and effusion tests were performed. Trefoil factor\u20103 (TFF\u20103), intestinal alkaline phosphatase (IAP), intestinal fatty acid binding protein (I\u2010FABP), myeloperoxidase\u2010anti\u2010neutrophilic cytoplasmic antibody (MPO\u2010ANCA) and proteinase 3\u2010ANCA (PR3\u2010ANCA) concentrations were measured both in serum and effusion samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rectal temperature and respiratory rate were highest in the TE group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.000). Effusion white blood cell count was higher in the AE group than TE group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.042). Serum TFF\u20103, IAP and I\u2010FABP concentrations were higher in cats with effusive FIP than the cats with FECV (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Compared with the AE group, TE group had lower effusion MPO\u2010ANCA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.036), higher IAP (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.050) and higher TFF\u20103 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.016) concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>Markers of intestinal and epithelial surface injury were higher in cats with effusive FIP than those with FECV. Compared to cats with abdominal effusions, markers of apoptosis inhibition and immunostimulation to the injured epithelium were more potent in cats with thoracic effusion, suggesting the possibility of a poorer prognosis or more advanced disease in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1299","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T03:11:30Z","timestamp":1698117090000},"page":"2420-2429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intestinal injury and vasculitis biomarkers in cats with feline enteric coronavirus and effusive feline infectious peritonitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-0150","authenticated-orcid":false,"given":"Erdem","family":"G\u00fclersoy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Veterinary Faculty Harran University \u015eanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-6735","authenticated-orcid":false,"given":"Mahmut","family":"Ok","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Veterinary Faculty Sel\u00e7uk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-4873","authenticated-orcid":false,"given":"Kamil","family":"\u00dcney","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Veterinary Faculty Sel\u00e7uk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat Kaan","family":"Durgut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Veterinary Faculty Sel\u00e7uk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba Melike","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Veterinary Faculty Sel\u00e7uk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Emre","family":"Ekici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Veterinary Faculty Sel\u00e7uk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"3223","article-title":"Trefoil factors in inflammatory bowel disease","volume":"28","author":"Aamann L.","year":"2017","journal-title":"World Journal of Gastroenterology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.05.010"},{"key":"e_1_2_11_4_1","first-page":"164","article-title":"Control of feline coronavirus infection in kittens","volume":"126","author":"Addie D. 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