{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:19:12Z","timestamp":1789049952661,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The tear clearance rate (TCR), determined using anterior segment optical coherence tomography (AS\u2010OCT) images, and its correlation with ocular surface parameters, including blink rate, Schirmer tear test\u20101 (STT\u20101) and tear film breakup time (TFBUT), were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Animals studied<\/jats:title>\n Left eyes of 20 client\u2010owned dogs with no ocular disease symptoms.<\/jats:p>\n <\/jats:sec>\n \n Procedures<\/jats:title>\n \n The tear meniscus height (TMH) was evaluated using AS\u2010OCT images before the instillation of 5\u00a0\u03bcL saline (TMH\n base<\/jats:sub>\n ), immediately post\u2010instillation (TMH\n 0<\/jats:sub>\n ), 30\u2010s post\u2010instillation (TMH\n 0.5<\/jats:sub>\n ) and at 1\u00a0min intervals for 5\u00a0min post\u2010instillation (TMH\n 1<\/jats:sub>\n , TMH\n 2<\/jats:sub>\n , TMH\n 3<\/jats:sub>\n , TMH\n 4<\/jats:sub>\n and TMH\n 5<\/jats:sub>\n ). The TCR was calculated using the formula [(TMH\n 0<\/jats:sub>\n \u00a0\u2212\u00a0TMH\n 0.5<\/jats:sub>\n )\/TMH\n 0<\/jats:sub>\n ]\u00d7100 (%). The eyes were classified into two groups with the median: \u2018High TMH\n base<\/jats:sub>\n \u2019 (\n n<\/jats:italic>\n \u00a0=\u00a010) and \u2018Low TMH\n base<\/jats:sub>\n \u2019 (\n n<\/jats:italic>\n \u00a0=\u00a010). Eyes with STT\u20101 values \u226515\u00a0mm\/min and TFBUT\u00a0\u2265\u00a012\u00a0s were assigned to the \u2018Satisfied\u2019 subgroup, whereas eyes not satisfying these criteria were assigned to the \u2018Not satisfied\u2019 subgroup.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n TMH\n 0<\/jats:sub>\n was higher than TMH\n 0.5<\/jats:sub>\n (\n p<\/jats:italic>\n \u00a0=\u00a00.02), wherein TMH\n 0.5<\/jats:sub>\n to TMH\n 5<\/jats:sub>\n did not differ significantly. The TCR and blink rate were negatively correlated (\n p<\/jats:italic>\n \u00a0=\u00a00.02). The \u2018Not satisfied\u2019 subgroup in the low TMH\n base<\/jats:sub>\n group had a lower TCR (\n p<\/jats:italic>\n \u00a0=\u00a00.02) and higher blink rate (\n p<\/jats:italic>\n \u00a0=\u00a00.04) than the \u2018Satisfied\u2019 subgroup.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n TCR can be evaluated using AS\u2010OCT in dogs. Eyes with a lower TCR blink more frequently. TMH merits studying to understand ocular surface health.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vms3.1334","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T13:21:02Z","timestamp":1702646462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tear clearance rate in dogs: Measurement using anterior segment optical coherence tomography"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8482-5912","authenticated-orcid":false,"given":"Hyun\u2010Jeong","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Veterinary Ophthalmology College of Veterinary Medicine, Konkuk University Gwangjin\u2010Gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangshin","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of Urban Public Health & Department of Urban Big Data Convergence University of Seoul Seoul Republic of Korea"},{"name":"Department of Pathology and Laboratory Medicine Alpert Medical School, Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-6269","authenticated-orcid":false,"given":"Joon\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Ophthalmology College of Veterinary Medicine, Konkuk University Gwangjin\u2010Gu Seoul Republic of Korea"},{"name":"KU Center for Animal Blood Medical Science Konkuk University Gwangjin\u2010Gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161\u20106420(99)90170\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13620\u2010021\u201000183\u20105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318242042b"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.08.003"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"632","article-title":"A mouse model of keratoconjunctivitis sicca","volume":"43","author":"Dursun D.","year":"2002","journal-title":"Investigative Ophthalmology & Visual Scienc"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2018.1435271"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13044"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100842"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689609008906"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010018\u20101593\u2010y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2003.10.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.09.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350\u20109462(98)00004\u20104"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","unstructured":"Williams D. &Denny E.(2020).Evaluation of blink rate in the normal dog. InBSAVA congress proceedings 2020(pp.461\u2013461).BSAVA Library.","DOI":"10.22233\/9781910443774.65.4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12260"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000997"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.1334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T09:32:54Z","timestamp":1710840774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.1334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/vms3.1334"],"URL":"https:\/\/doi.org\/10.1002\/vms3.1334","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.1334\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1334\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1334\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1334\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1334\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1334\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1334\/v2\/review1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"assertion":[{"value":"2023-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1334"}}