{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:56:45Z","timestamp":1790485005322,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rift Valley fever (<jats:styled-content style=\"fixed-case\">RVF<\/jats:styled-content>) is a mosquito\u2010borne viral zoonosis causing abortions and high mortality among animals, whereas in humans, the disease is usually mild or asymptomatic. In September 2016, the Republic of Niger declared the first <jats:styled-content style=\"fixed-case\">RVF<\/jats:styled-content> outbreak in the northern region of Tahoua near the Malian border. This study describes the outbreak and reports the results of serological and molecular investigations of the human and animal samples collected. Serum samples from both human and animal suspected cases have been confirmed at the Centre de Recherche M\u00e9dicale et Sanitaire (<jats:styled-content style=\"fixed-case\">CERMES<\/jats:styled-content>) and the Laboratoire Centrale d'Elevage (<jats:styled-content style=\"fixed-case\">LABOCEL<\/jats:styled-content>) public health and animal reference laboratories, respectively. Techniques for biological confirmation were real time reverse transcription polymerase chain reaction (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) and enzyme linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). Phylogenetic trees were established after genetic sequencing of the small and medium segments of the <jats:styled-content style=\"fixed-case\">RVF<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">RVFV<\/jats:styled-content>) genome. Out of the 399 human samples collected, 17 (4.3%) were confirmed positive for <jats:styled-content style=\"fixed-case\">RVFV<\/jats:styled-content>. Overall, 33 (8.3%) deaths occurred out of which five (29%) were among the 17 confirmed cases. Regarding animals, 45 samples were tested, three of which were <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> positive and 24 were IgG positive. The phylogenetic analyses showed that the Niger strains clustered with Senegal 2013 and Mauritania 2015 <jats:styled-content style=\"fixed-case\">RVFV<\/jats:styled-content> strains. This first outbreak of <jats:styled-content style=\"fixed-case\">RVF<\/jats:styled-content> was very challenging for public and animal health laboratories in Niger. Besides resulting in human deaths, important loss of cattle has been reported. Therefore, vigilance has to be strengthened emphasising vector control strategies and active surveillance among animals.<\/jats:p>","DOI":"10.1002\/vms3.135","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T12:09:49Z","timestamp":1541765389000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["First occurrence of Rift Valley fever outbreak in Niger, 2016"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-9048","authenticated-orcid":false,"given":"Adamou","family":"Lagare","sequence":"first","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamou","family":"Fall","sequence":"additional","affiliation":[{"name":"Arbovirus and Viral Hemorrhagic Fevers Unit Institut Pasteur Dakar S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkassoum","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Minist\u00e8re de la Sant\u00e9 Publique (MSP) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sani","family":"Ousmane","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bacary","family":"Sadio","sequence":"additional","affiliation":[{"name":"Arbovirus and Viral Hemorrhagic Fevers Unit Institut Pasteur Dakar S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariama","family":"Abdoulaye","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdou","family":"Alhassane","sequence":"additional","affiliation":[{"name":"Laboratoire Centrale d'Elevage (LABOCEL) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Elh","family":"Mahaman","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassira","family":"Issaka","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fati","family":"Sidikou","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maman","family":"Zaneidou","sequence":"additional","affiliation":[{"name":"Minist\u00e8re de la Sant\u00e9 Publique (MSP) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruani","family":"Bienvenue","sequence":"additional","affiliation":[{"name":"World Health Organization Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harouna","family":"Djingarey Mamoudou","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Office for Africa Brazzaville Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Bailo Diallo","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Office for Africa Brazzaville Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goumbi","family":"Kadad\u00e9","sequence":"additional","affiliation":[{"name":"Minist\u00e8re de la Sant\u00e9 Publique (MSP) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Testa","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Boubacar Mainassara","sequence":"additional","affiliation":[{"name":"Centre de Recherche M\u00e9dicale et Sanitaire (CERMES) Niamey Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousmane","family":"Faye","sequence":"additional","affiliation":[{"name":"Arbovirus and Viral Hemorrhagic Fevers Unit Institut Pasteur Dakar S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,9]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"321","article-title":"Epidemiology of Rift Valley fever in western Africa. I. Serologic survey in domestic ruminants of Burkina Faso","volume":"82","author":"Akakpo A.J.","year":"1989","journal-title":"Bulletin de la Societe de Pathologie Exotique et de Ses Filiales"},{"key":"e_1_2_11_3_1","first-page":"217","article-title":"Epidemiology of Rift Valley fever in West Africa. 1. Serological investigation of small ruminants in Niger","volume":"84","author":"Akakpo A.J.","year":"1991","journal-title":"Bulletin de la Societe de Pathologie Exotique (1990)"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx087"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw200"},{"key":"e_1_2_11_6_1","first-page":"73","article-title":"Rift Valley fever outbreak\u2013Kenya, November 2006\u2010January 2007","volume":"56","author":"Centers for Disease Control and Prevention","year":"2007","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700340418"},{"key":"e_1_2_11_8_1","article-title":"Aspects \u00c9pid\u00e9miologiques, Cliniques et \u00c9volutifs des Cas Compliqu\u00e9s de Fi\u00e8vre de la Vall\u00e9e du Rift au District Sanitaire de Tchintabaraden (Niger)","volume":"18","author":"Doutchi M.","year":"2017","journal-title":"Health Science and Disease"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2016.1967"},{"key":"e_1_2_11_10_1","unstructured":"Food and Agriculture Organization. (2017)Rift Valley fever in Niger. Animal health risk analysis 1.http:\/\/www.fao.org\/3\/a-i7055e.pdf(assessed on 14 June 2017)"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1175\/JHM-D-13-0134.1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001229"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2014.00169"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v3050493"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92753-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0769-2617(88)80046-7"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607948114"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/378747"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.217"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2010.0200"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004783"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-0993-8"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3402\/iee.v5.28024"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005226"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw149"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2516(91)90029-3"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.001"},{"key":"e_1_2_11_29_1","unstructured":"World Health Organization. (2016)Rift Valley fever in Niger. Emergencies preparedness response.http:\/\/www.who.int\/csr\/don\/29-September-2016-rift-valley-fever-niger\/en\/(assessed on 15 march 2017)."}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fvms3.135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:21:08Z","timestamp":1694686868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,9]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/vms3.135"],"URL":"https:\/\/doi.org\/10.1002\/vms3.135","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,9]]},"assertion":[{"value":"2018-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}