{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:00Z","timestamp":1786978560386,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Various anti\u2010parasitic drugs are used to control donkey parasitic diseases. The abuse of donkey drugs leads to the disposition of residues in the edible parts of treated donkeys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to (1) analyse the pharmacokinetics of ABZSO to serve as reference for the dosage regimen in donkey; and (2) calculate the withdrawal times of the ABZSO in the tissue of the donkey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The concentrations of ABZSO and its metabolites in plasma and tissues were determined using high\u2010performance liquid chromatography with an ultraviolet detector. Pharmacokinetic analysis was performed by the programme 3p97.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The plasma concentrations of ABZSO and ABZSO\n                      <jats:sub>2<\/jats:sub>\n                      concentration\u2013time data in donkey conformed to the absorption one\u2010compartment open model. The  of ABZSO was 0.67\u00a0h, whereas the\n                      <jats:italic>t<\/jats:italic>\n                      <jats:sub>1\/2<\/jats:sub>\n                      <jats:italic>\n                        <jats:sub>k<\/jats:sub>\n                      <\/jats:italic>\n                      <jats:sub>e<\/jats:sub>\n                      was 12.93\u00a0h; the\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      and the\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>p<\/jats:sub>\n                      were calculated as 0.58\u00a0\u03bcg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      and 3.01\u00a0h. The\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>d\/F<\/jats:sub>\n                      of ABZSO was estimated to be 10.92 L\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ; the area under the curve (AUC) was 12.81\u00a0\u03bcg\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00a0h. The\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      and AUC values of ABZSO were higher than those of ABZSO\n                      <jats:sub>2<\/jats:sub>\n                      ; however,\n                      <jats:italic>t<\/jats:italic>\n                      <jats:sub>1\/2<\/jats:sub>\n                      <jats:italic>\n                        <jats:sub>K<\/jats:sub>\n                      <\/jats:italic>\n                      <jats:sub>e<\/jats:sub>\n                      and\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>d\/F<\/jats:sub>\n                      were lower. Other pharmacokinetics parameters were similar between the two metabolites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results revealed that ABZSO\n                      <jats:sub>2<\/jats:sub>\n                      was the main metabolite of ABZSO in donkey plasma. The concentrations of ABZSO and its chief metabolite (ABZSO\n                      <jats:sub>2<\/jats:sub>\n                      ) were detected in liver, kidney, skin and muscle; however, ABZ\u2010SO\n                      <jats:sub>2<\/jats:sub>\n                      NH\n                      <jats:sub>2<\/jats:sub>\n                      was only detected in liver and kidney. The results also revealed that the depletion of ABZSO and its metabolite in donkey was longer, especially in skin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1393","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:09:50Z","timestamp":1713532190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics and tissue residues of albendazole sulphoxide and its metabolites in donkey after intramuscular injection"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-417X","authenticated-orcid":false,"given":"Zaijian","family":"Li","sequence":"first","affiliation":[{"name":"College of Agricultural Science and Engineering Liaocheng University  Liaocheng Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4233-8485","authenticated-orcid":false,"given":"Xuling","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering Liaocheng University  Liaocheng Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5186-1703","authenticated-orcid":false,"given":"Changfa","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering Liaocheng University  Liaocheng Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-0467","authenticated-orcid":false,"given":"Wenqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Agricultural Science and Engineering Liaocheng University  Liaocheng Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.116106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.04.049"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2019.1695276"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2017.1400186"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006496122684"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005945"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2017.608.283"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-016-5365-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2001.00328.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026008010899"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112249"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.04.031"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12897"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2017-0090"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341307780619224"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2021.1954700"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1638\/2018-0120"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2020.1719285"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2020.20.e29"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sscp.202100024"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122016"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.1393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T03:44:26Z","timestamp":1717991066000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.1393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,19]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/vms3.1393"],"URL":"https:\/\/doi.org\/10.1002\/vms3.1393","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.1393\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1393\/v3\/decision1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,19]]},"assertion":[{"value":"2023-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1393"}}