{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:07:04Z","timestamp":1790352424482,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2023\u2010DD\u2010UP\u20100031"],"award-info":[{"award-number":["2023\u2010DD\u2010UP\u20100031"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      No tick\u2010borne pathogens (TBPs) causing haemolytic anaemia in cattle have been reported, except\n                      <jats:italic>Theileria orientalis<\/jats:italic>\n                      and complete blood count (CBC) profile is the only haematological parameter to determine the severity of regenerative haemolytic anaemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify the causative agents of TBP\u2010induced haemolytic anaemia and determine haematological parameters that indicate haemolytic anaemia in grazing cattle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010two Korean indigenous cattle (Hanwoo) were divided into two groups: grazing (\n                      <jats:italic>n<\/jats:italic>\n                      = 67) and indoor (\n                      <jats:italic>n<\/jats:italic>\n                      = 15) groups. CBC and serum biochemistry were performed. PCR was conducted using whole blood\u2010extracted DNA to investigate the prevalence of TBPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TBP\u2010induced haemolytic anaemia was observed in the grazing group. In grazing cattle, co\u2010infection (43.3%, 29\/67) was most frequently detected, followed by\n                      <jats:italic>T. orientalis<\/jats:italic>\n                      (37.6%, 25\/67) and\n                      <jats:italic>Anaplasma phagocytophilum<\/jats:italic>\n                      infections (1.5%, 1\/67). In indoor cattle, only co\u2010infection (20%, 3\/15) was identified. Grazing cattle exhibited regenerative haemolytic anaemia with marked monocytosis, mild neutropenia, and thrombocytopenia. According to grazing frequency, the 1st\u2010time grazing group had more severe anaemia than the 2nd\u2010time grazing group. Elevations in indirect bilirubin and L\u2010lactate due to haemolytic anaemia were identified, and correlations with the respective markers were determined in co\u2010infected grazing cattle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Quantitative evaluation of haematocrit, mean corpuscular volume, and reticulocytes (markers of regenerative haemolytic anaemia in cattle) was performed for the first time. Our results show that, in addition to\n                      <jats:italic>T. orientalis<\/jats:italic>\n                      ,\n                      <jats:italic>A. phagocytophilum<\/jats:italic>\n                      is strongly associated with anaemia. The correlation between haemolytic anaemia severity and haematological parameters (indirect bilirubin, reticulocytes, and L\u2010lactate) was confirmed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1434","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T08:45:04Z","timestamp":1712133904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of haematological parameters in haemolytic anaemia caused by tick\u2010borne pathogens in grazing cattle"],"prefix":"10.1002","volume":"10","author":[{"given":"Youngjun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Jeonbuk University  Iksan Republic of Korea"},{"name":"Department of Animal Hospital, Hanwoo (Korean Indigenous Cattle) Genetic Improvement Center National Agricultural Cooperative Federation  Seosan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Young","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Jeonbuk University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngwoo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine College of Veterinary Medicine Jeonbuk University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hwan","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Animal Hospital, Hanwoo (Korean Indigenous Cattle) Genetic Improvement Center National Agricultural Cooperative Federation  Seosan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jeong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, College of Ecology and Environmental Science Kyungpook National University  Sangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, College of Ecology and Environmental Science Kyungpook National University  Sangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Chul","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, College of Ecology and Environmental Science Kyungpook National University  Sangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-5360","authenticated-orcid":false,"given":"Kyoung\u2010Seong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, College of Ecology and Environmental Science Kyungpook National University  Sangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Animal Hospital, Hanwoo (Korean Indigenous Cattle) Genetic Improvement Center National Agricultural Cooperative Federation  Seosan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9090697"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2022.106780"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936\u2010001\u20100070\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010015\u20104698\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865\u20101682.2010.01173.x"},{"key":"e_1_2_10_7_1","volume-title":"Blackwell's five\u2010minute veterinary consult: ruminant","author":"Chase C.","year":"2017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2016.03.018"},{"key":"e_1_2_10_9_1","volume-title":"Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs and goats","author":"Constable P. D.","year":"2016"},{"key":"e_1_2_10_10_1","first-page":"2286","volume-title":"Encyclopedia of immunology","author":"Delves P. J.","year":"1998"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(09)70296\u20108"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11080912"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12937"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.04.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vprsr.2016.12.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2004.06.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1990.51.07.1026"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2007.07.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20103305\u20104\u201022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2017.55.5.481"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2000.tb05329.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090\u20103558\u201020.1.12"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vprsr.2018.09.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.9.1458"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2017.07.035"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027970"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010019\u20102042\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028\u2010018\u20100370\u2010z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010016\u20105316\u20107"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2007.07.003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00415"},{"key":"e_1_2_10_33_1","volume-title":"Schalm's veterinary hematology","author":"Schalm O.","year":"2010"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2019.2609"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.07.013"},{"key":"e_1_2_10_36_1","volume-title":"Large animal internal medicine","author":"Smith B. P.","year":"2020"},{"key":"e_1_2_10_37_1","first-page":"640","volume-title":"Fundamentals of veterinary clinical pathology","author":"Stockham S. L.","year":"2008"},{"key":"e_1_2_10_38_1","first-page":"110","volume-title":"Fundamentals of veterinary clinical pathology","author":"Stockham S. L.","year":"2008"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35775-3.00004-7"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.1434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T03:45:49Z","timestamp":1717991149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.1434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/vms3.1434"],"URL":"https:\/\/doi.org\/10.1002\/vms3.1434","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.1434\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1434\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1434\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1434\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.1434\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"assertion":[{"value":"2023-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1434"}}