{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:44:48Z","timestamp":1785797088885,"version":"3.56.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A significant association between atopic dermatitis and leaky gut syndrome has been demonstrated in humans. No studies have been conducted to determine whether there is an association between atopic dermatitis and intestinal damage in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to determine whether there is an association between canine atopic dermatitis and intestinal damage using selected intestinal\u2010related biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six dogs with atopic dermatitis and 10 healthy dogs were included. Moderate\u2010to\u2010severe pruritus, erythema, erosion and alopecia on different parts of the body were sought in dogs to suspect atopic dermatitis. The presence of atopic dermatitis was confirmed by an allergic skin test.\u00a0Serum biomarkers including intestinal fatty acid binding protein (I\u2010FABP), intestinal alkaline phosphatase (IAP), trefoil factor\u20103 (TFF\u20103), immunoglobulin E (IgE), interleukin\u20104 (IL\u20104) and interleukin\u201013 (IL\u201013) concentrations were measured from venous blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 26 dogs tested for allergens, 16 were found to be sensitive to mould mites, 10 to vernal grass, eight to house dust mites, five to wheat dust and five to grass pollen mix allergens. Significant increases in serum IAP, TFF\u20103, IgE, IL\u20104 and IL\u201013 concentrations were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was thought that the increase in TFF\u20103 and IAP concentrations may be due to the presence of intestinal epithelial damage and the repair of this damage. In addition, the development of atopic dermatitis may be predisposed to the entry of allergens into the body through sites of intestinal damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.1453","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T17:23:35Z","timestamp":1713806615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-1169","authenticated-orcid":false,"given":"Yusuf Emre","family":"Ekici","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-6735","authenticated-orcid":false,"given":"Mahmut","family":"Ok","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Veterinary Medicine Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"3223","article-title":"Trefoil factors in inflammatory bowel disease","volume":"28","author":"Aamann L.","year":"2017","journal-title":"World Journal of Gastroenterology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.05.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2022.1996-2003"},{"key":"e_1_2_11_5_1","first-page":"739","article-title":"Does the epithelial barrier hypothessis explain the increase in allergy, autoimmunity and other chronic conditions?","volume":"21","author":"Akdis C. 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