{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:20:00Z","timestamp":1791606000955,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The metabolic changes that occur during the early post\u2010partum period in dairy cows can indeed lead to an imbalance in energy utilization, resulting in the production of excessive ketone bodies. This can have detrimental effects on the cow's health and milk production, leading to economic losses for dairy producers. The release of non\u2010esterified fatty acids into the blood due to increased lipolysis is a key factor in the development of ketosis. Abdominal adiposity is a key factor on these outcomes in modern dairy cows. The redirection of energy and glucose towards lactose synthesis and milk yield leaves a deficit of gluconeogenic precursors, leading to the conversion of acetyl\u2010CoA into ketone bodies instead of entering the Krebs cycle. These ketone bodies, including acetone, acetoacetate and \u03b2\u2010hydroxybutyrate, accumulate in the blood and can be detected in various bodily fluids, such as urine, blood and milk, allowing for diagnostic testing. Prevention is indeed crucial in managing ketosis in dairy cattle. Supplementation of propylene glycol in the diet or the use of monensin, either in the diet or in the form of a slow\u2010release bolus, can help prevent the occurrence of ketosis. However, avoiding high body condition (subcutaneous fat) and excessive abdominal adiposity during the dry period and parturition plus an adequate cow comfort are fundamental tasks to avoid ketosis and related disorders. These interventions aim to provide additional energy sources or enhance the cow's ability to utilize energy efficiently, thus reducing the reliance on excessive lipolysis and ketone body production.<\/jats:p>","DOI":"10.1002\/vms3.1525","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T07:19:55Z","timestamp":1725002395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Update on ketosis in dairy cattle with major emphasis on subclinical ketosis and abdominal adiposity"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-9244","authenticated-orcid":false,"given":"Pedro","family":"Melendez","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Jockey Club College of Veterinary Medicine &amp; Life Sciences City University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Vizcaino","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Jockey Club College of Veterinary Medicine &amp; Life Sciences City University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167\u20105877(99)00017\u20103"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5877(85)90006-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2011.02.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-7163"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2020\u201019111"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(04)73511\u20100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2021-20855"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2023-23409"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14010144"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2014.999841"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2013.823829"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2017\u201013340"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1272162"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2013.04.002"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031582\u20104"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(01)70204-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2008\u20101507"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2011.12.009"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12141"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(01)70170-1"},{"key":"e_1_2_12_22_1","first-page":"728","article-title":"The cost of a case of subclinical ketosis in Canadian dairy herds","volume":"57","author":"Gohary K.","year":"2016","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_12_23_1","unstructured":"Gordon J. 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