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Acepromazine (0.02\u00a0mg\/kg) and methadone (0.5\u00a0mg\/kg) were administered intramuscularly for sedation, propofol (2\u00a0mg\/kg) and midazolam (0.2\u00a0mg\/kg) were administered intravenously for anaesthetic induction and isoflurane in oxygen was utilised for anaesthetic maintenance. Rocuronium (0.5\u00a0mg\/kg), a neuromuscular blocking agent, was administered intravenously to facilitate central positioning of the eye for surgery. Within 10\u00a0min of rocuronium administration, the dog became tachycardic and hypotensive. Hemodynamic aberrations did not resolve with initial interventions but were successfully mitigated with the administration of diphenhydramine (0.8\u00a0mg\/kg) intravenously. The dog remained stable throughout the remainder of the procedure and experienced a smooth and uneventful recovery. While it is difficult to confirm that the hemodynamic changes observed in this clinical case resulted solely from administration of rocuronium, the observance of the cardiovascular changes, timing of events and response to therapy suggest that rocuronium elicited a histamine response that was successfully treated with diphenhydramine.<\/jats:p>","DOI":"10.1002\/vms3.1531","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T03:14:19Z","timestamp":1719890059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Occurrence of hemodynamic changes following administration of rocuronium in a dog presenting for an ophthalmic procedure"],"prefix":"10.1002","volume":"10","author":[{"given":"Melissa","family":"Calus","sequence":"first","affiliation":[{"name":"Veterinary Medical Center, College of Veterinary Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2147-964X","authenticated-orcid":false,"given":"Kirk A.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9901021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2987.2001.00057.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-070202035-3.50005-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13054"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01313.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2016-000343"},{"key":"e_1_2_9_8_1","first-page":"1079","volume-title":"Allergy principles and practice","author":"Lieberman P.","year":"1998"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000516"},{"key":"e_1_2_9_10_1","first-page":"57","article-title":"Anaesthesia\u2010related anaphylaxis: Investigation and follow\u2010up","volume":"14","author":"Mills A.","year":"2014","journal-title":"BJA Education"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198310000-00011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/75.5.588"},{"key":"e_1_2_9_13_1","first-page":"856","article-title":"Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery","volume":"52","author":"Ortega M.","year":"2011","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_9_14_1","first-page":"412","volume-title":"Anesthesia","author":"Savarese J. 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