{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:54Z","timestamp":1772118954403,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This field evaluation was designed to evaluate the efficacy of a new porcine reproductive and respiratory syndrome virus\u20102 (PRRSV\u20102) modified live virus vaccine at three independent pig farms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three farms were selected for this study based on their respiratory disease status caused by PRRSV\u20102 infection in post\u2010weaning and growing pigs. Each farm housed a total of 40, 18\u2010day\u2010old pigs that were randomly allocated to one of two treatment groups. Pigs were administered a 1.0\u00a0mL dose of the bivalent vaccine intramuscularly at 21 days of age in accordance with the manufacturer's recommendations, whereas unvaccinated pigs were administered a single dose of phosphate buffered saline at the same age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vaccinated groups were measured and calculated significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) higher in body weight and average daily weight gain on all three farms compared with unvaccinated groups. Vaccinated groups elicited PRRS antibodies and PRRSV\u20102\u2010specific interferon\u2010\u03b3 secreting cells, which reduced the amount of PRRSV\u20102 genomic copies in the blood and reduced macroscopic and microscopic lung lesions severity when compared with unvaccinated groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The field evaluation data demonstrated that a new PRRSV\u20102 modified live virus vaccine was efficacious in swine herds suffering from respiratory diseases caused by PRRSV\u20102 infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1540","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:42:03Z","timestamp":1720179723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Field efficacy of a novel porcine reproductive and respiratory syndrome modified\u2010live virus vaccine with an emphasis on growth performance"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-5597","authenticated-orcid":false,"given":"Sehyeong","family":"Ham","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1804-0860","authenticated-orcid":false,"given":"Hyunjoon","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-911X","authenticated-orcid":false,"given":"Jeongmin","family":"Suh","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chonghan","family":"Kim","sequence":"additional","affiliation":[{"name":"WOOGENE B&amp;G Co., Ltd. Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Ju","family":"Kwon","sequence":"additional","affiliation":[{"name":"WOOGENE B&amp;G Co., Ltd. Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeong\u2010Seo","family":"Park","sequence":"additional","affiliation":[{"name":"WOOGENE B&amp;G Co., Ltd. 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