{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:13:15Z","timestamp":1789182795165,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008257","name":"Tarbiat Modares University","doi-asserted-by":"publisher","award":["8930182003"],"award-info":[{"award-number":["8930182003"]}],"id":[{"id":"10.13039\/501100008257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our hypothesis centred on the potential to mitigate ascites outbreaks in birds exposed to cold stress by inhibiting pulmonary artery contraction through dietary intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect of natural and synthetic medications on growth performance, ascites\u2010related parameters and the expression of ascites\u2010related genes in the lung tissue of broiler chickens under low ambient temperature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We randomly assigned 450 one\u2010day\u2010old male Ross 308 chicks to six dietary treatments across five replicate pens, each containing 15 chicks. The treatments included a basal diet (control), and the basal diet was supplemented with hydroalcoholic extracts of sumac (HES, 200\u00a0mg\/kg), Syrian mesquite (HEM, 200\u00a0mg\/kg),\n                      <jats:sc>l<\/jats:sc>\n                      \u2010arginine (40% above requirement), captopril (15\u00a0mg\/kg) and vitamin E (100\u00a0mg\/kg).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diets containing HEM,\n                      <jats:sc>l<\/jats:sc>\n                      \u2010arginine and vitamin E resulted in increased average daily gain on days 8\u201314 and 0\u201328, whereas HES showed a similar effect only during days 8\u201314 compared to the control diet (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Additionally, feed additives decreased packed cell volume, left and right ventricle volumes and systolic blood pressure (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Moreover, chickens fed the control and\n                      <jats:sc>l<\/jats:sc>\n                      \u2010arginine diets exhibited higher levels of angiotensin converting enzyme (ACE) mRNA in lung tissue compared to those fed HES, HEM and captopril (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Meanwhile, supplementation with HEM and\n                      <jats:sc>l<\/jats:sc>\n                      \u2010arginine increased the expression of inducible nitric oxide synthase (iNOS) mRNA in lung tissue compared to other treatments (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05). Regarding Cu\/Zn\u2010superoxide dismutase (Cu\/Zn\u2010SOD) expression, feed additives increased mRNA level in lung tissue, except for captopril (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that the plant extracts may reduce the incidence of ascites syndrome not only through their antioxidant properties but also by modulating the expression of ACE, iNOS and Cu\/Zn\u2010SOD genes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1542","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:52:58Z","timestamp":1721879578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diets containing phytobiotics,\n                    <scp>l<\/scp>\n                    \u2010arginine, vitamin E and captopril modulate ascites syndrome\u2010related genes expression in broiler chickens exposed to low ambient temperature"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-5392","authenticated-orcid":false,"given":"Hassan","family":"Shirzadi","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture Ilam University Ilam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-6030","authenticated-orcid":false,"given":"Farid","family":"Shariatmadari","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Faculty of Agriculture Tarbiat Modares University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8141-4904","authenticated-orcid":false,"given":"Mohammad 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