{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:54:05Z","timestamp":1781877245406,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007298","name":"Urmia University","doi-asserted-by":"publisher","award":["PD\/1400\/11\/03"],"award-info":[{"award-number":["PD\/1400\/11\/03"]}],"id":[{"id":"10.13039\/501100007298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infectious bronchitis (IB) is an important disease of poultry, and vaccination is the best method of preventing IB in the poultry industry worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was designed to evaluate cytokine and acute\u2010phase protein (APP) responses and their correlations with antibody titres following vaccination regimes against IB in the broiler.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Broilers were vaccinated with H120 and 1\/96 vaccine strains, and MIX (H120\u00a0+\u00a01\/96) vaccine strains on Days 0 and 14. Heterophils\/lymphocyte (H\/L) ratio, APPs including chicken serum amyloid A (SAA), chicken pentraxin 3 (chPTX3), chicken interleukin 1\u03b2 (IL\u20101\u03b2), chicken interleukin 6 (IL\u20106) levels and antibody titres were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An increase in the H\/L ratio, SAA, chPTX3, IL\u20101\u03b2 and IL\u20106 levels in vaccinated groups was observed 1 day after the first (highest rates) and second (lower levels) vaccination up to 3 days in three different patterns and then started to decrease. The results showed an immediate, short\u2010lived response and moderate increases in all criteria. Changing patterns of APPs were different but in similar pattern after the first and second immunization in vaccinated groups. A positive correlation between all criteria values on Days 1 and 15 with antibody titres on Day 28 may indicate agonistic cross\u2010regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Different types of IB vaccines could induce different patterns of APPs responses, which can be used to evaluate immune response outcomes in vaccine design, development and administration. The IL\u20106 with the highest increase can be a sensitive parameter and chPTX3 with the high increase could be an important criterion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.1586","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:32:09Z","timestamp":1724340729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytokine and acute\u2010phase proteins response following vaccination against infectious bronchitis in broilers"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1352-4148","authenticated-orcid":false,"given":"Dana","family":"Anousheh","sequence":"first","affiliation":[{"name":"Department of Poultry Health &amp; Diseases Faculty of Veterinary Medicine Urmia University  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-0014","authenticated-orcid":false,"given":"Manoochehr","family":"Allymehr","sequence":"additional","affiliation":[{"name":"Department of Poultry Health &amp; Diseases Faculty of Veterinary Medicine Urmia University  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-0488","authenticated-orcid":false,"given":"Alireza","family":"Talebi","sequence":"additional","affiliation":[{"name":"Department of Poultry Health &amp; Diseases Faculty of Veterinary Medicine Urmia University  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-3290","authenticated-orcid":false,"given":"Siamak","family":"Asri\u2010Rezaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Faculty of Veterinary Medicine Urmia University  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"557","article-title":"Chronic amyloid arthropathy and increased serum amyloid levels in brown layers","volume":"50","author":"Alasonyalilar A.","year":"2006","journal-title":"Bulletin of the Veterinary Institute in Pulawy"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00124"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580\u2010014\u20102052\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/peu009"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"517","article-title":"Acute phase response in animals: A review","volume":"59","author":"Cray C.","year":"2009","journal-title":"Comparative Medicine"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4081\/vsd.2014.5416"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079450094108"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u2010736X2015000300002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1917"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/1590198"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2005.B0941"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2005.B1045"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297\u20109716\u201042\u201050"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/1592456"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975\u20107406.76489"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013\u201003116"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex340"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2020.1276"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580\u2010009\u20100939\u2010z"},{"key":"e_1_2_10_23_1","unstructured":"O'Reilly E. 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