{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:37:30Z","timestamp":1773005850564,"version":"3.50.1"},"reference-count":134,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mast cell neoplasia clinical presentation and biological behaviour vary considerably across mammalian species, ranging from a solitary benign mass to an aggressive systemic malignancy. Mutations in the <jats:italic>KIT Proto\u2010Oncogene Receptor Tyrosine Kinase (KIT)<\/jats:italic> gene are common molecular abnormalities involved in mast cell tumorigenesis<jats:italic>. KIT<\/jats:italic> mutations often occur in dog, cat and human neoplastic mast cells and result in altered Kit protein structure and function. In dogs, certain <jats:italic>KIT<\/jats:italic> mutations are associated with more malignant and lethal disease. In contrast, <jats:italic>KIT<\/jats:italic> mutations in feline and human mast cell neoplasms are not correlated with prognosis, but are of value in diagnosis and treatment planning in humans. <jats:italic>KIT<\/jats:italic> genetic abnormalities have not been well investigated in other species, although aberrant cytoplasmic Kit protein staining detected in neoplasms of the ferret, horse and cow resembles aberrant Kit staining patterns detected in neoplastic mast cells of dogs, cats and humans. Mutations within <jats:italic>KIT<\/jats:italic> are classified as either regulatory\u2010type or enzymatic pocket\u2010type mutations according to their location within the <jats:italic>KIT Proto\u2010Oncogene<\/jats:italic>. Mutations within the enzymatic pocket domain confer tumour resistance to tyrosine kinase inhibitors (TKIs). Hence, knowledge of tumour <jats:italic>KIT<\/jats:italic> mutation status adds valuable information for optimizing patient treatment strategies. The use of TKIs in combination with conventional chemotherapeutics has opened a new treatment avenue for patients unresponsive to existing drugs. This review highlights the similarities and differences of mast cell neoplasia in mammals with a special focus on the involvement of <jats:italic>KIT<\/jats:italic> in the canine and feline forms in comparison to human mast cell neoplasia.<\/jats:p>","DOI":"10.1002\/vms3.201","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T06:47:21Z","timestamp":1571986041000},"page":"3-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparative aspects of mast cell neoplasia in animals and the role of <i>KIT<\/i> in prognosis and treatment"],"prefix":"10.1002","volume":"6","author":[{"given":"Vanessa S.","family":"Tamlin","sequence":"first","affiliation":[{"name":"School of Animal and Veterinary Sciences The University of Adelaide Roseworthy SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia D. K.","family":"Bottema","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences The University of Adelaide Roseworthy SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-2415","authenticated-orcid":false,"given":"Anne E.","family":"Peaston","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences The University of Adelaide Roseworthy SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Agricultural and Veterinary Chemicals. (2011).Toceranib phosphate in the products Palladia 50mg Palladia 15mg and Palladia 10mg. Kingston ACT: Commonwealth of Australia Gazette.17\u201320. Retrieved fromhttps:\/\/wol-prod-cdn.literatumonline.com\/pb-assets\/assets\/14765829\/01%20Guide%20to%20AMA%20Manual%20of%20Style.pdf. Published December 6 2011."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.149.18.560"},{"key":"e_1_2_9_4_1","volume-title":"U.S. Food and Drug Administration","author":"Anon","year":"2009"},{"key":"e_1_2_9_5_1","volume-title":"Masivet: European Public Assessment Report. European Medicines Agency","author":"Anon","year":"2013"},{"key":"e_1_2_9_6_1","volume-title":"Conditional approval explained: A resource for veterinarians","author":"Anon","year":"2018"},{"key":"e_1_2_9_7_1","volume-title":"Palladia: European Public Assessment Report. European Medicines Agency","author":"Anon","year":"2019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005647"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0901-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12326"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.04.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17695898"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.h4514"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00341.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.281"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588201900412"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13573"},{"issue":"8","key":"e_1_2_9_18_1","first-page":"959","article-title":"Benign cutaneous mastocytomas in two litters of Siamese kittens","volume":"193","author":"Chastain C. B.","year":"1988","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"123","article-title":"Benign cutaneous mast cell tumor in a rhesus monkey","volume":"46","author":"Colgin L. M.","year":"1996","journal-title":"Laboratory Animal Science"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1647\/2011-019.1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085362"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1638\/1042-7260(2003)34[0100:VMCTIA]2.0.CO;2"},{"issue":"1","key":"e_1_2_9_23_1","first-page":"2","article-title":"Clinical activity in a phase 1 study of Blu-285, a potent, highly-selective inhibitor of KIT D816V in advanced systemic mastocytosis (AdvSM)","volume":"130","author":"DeAngelo D. J.","year":"2017","journal-title":"Blood"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1718"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.477.477"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12305"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12408"},{"issue":"5","key":"e_1_2_9_28_1","first-page":"885","article-title":"Diagnosis and surgical treatment of reptilian neoplasms with a compilation of cases 1966\u20131993","volume":"8","author":"Frye F. L.","year":"1994","journal-title":"In Vivo"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116761"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.03.024"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638711425945"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11339"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.079202"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1638\/1042-7260-44.1.189"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.05.007"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03627.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079459708419242"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.11.1354"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0190.x"},{"key":"e_1_2_9_40_1","unstructured":"Hall S. Mosier D. &Degraw M.(1994).Histological and ultrastructural characterization of a cutaneous mast cell tumor in a chicken. Paper presented at: 43rd Western Poultry Disease Conference1994; Sacramento CA."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-10-105"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00206.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004320050262"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870902100128"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800514"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-1988-0"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817747325"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.07.004"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07926.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1964.1964"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.284"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.4"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587200900209"},{"issue":"3","key":"e_1_2_9_54_1","first-page":"558","article-title":"Comparative aspects of mastocytosis in man and animals with report of a case in a baboon","volume":"24","author":"Jones S. R.","year":"1974","journal-title":"Laboratory Animal Science"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589503200616"},{"issue":"2","key":"e_1_2_9_56_1","first-page":"68","article-title":"Immunohistochemical and morphopathological features of multiple cutaneous mast cell tumor in a cow","volume":"8","author":"Khodakaram\u2010Tafti A.","year":"2015","journal-title":"Brazilian Journal of Veterinary Pathology"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00830.x"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.04.002"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810386469"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2005.00726.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00185.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.15654\/TPK-140165"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2004-0117"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0067"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063871002200531"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.02.002"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(98)00075-7"},{"issue":"7","key":"e_1_2_9_68_1","first-page":"2755","article-title":"Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies","volume":"9","author":"London C. A.","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1860"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00028-5"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31403-9"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00488.x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.2746\/095777308X291804"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12425"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12266"},{"issue":"11","key":"e_1_2_9_76_1","first-page":"1258","article-title":"Gastric mast cell tumor in a cougar","volume":"187","author":"Martin H. D.","year":"1985","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12225"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10577-016-9543-7"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12241"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.166"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.1.91"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.158.9.287"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.154.24.743"},{"key":"e_1_2_9_84_1","first-page":"9","article-title":"Practical issues in calculating the sample size for prevalence studies","volume":"1","author":"Naing L.","year":"2006","journal-title":"Archives of Orofacial Science"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2017.05.004"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.13-0156"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712452725"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.106"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1638\/2008-068.1"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"issue":"4","key":"e_1_2_9_91_1","first-page":"298","article-title":"A case of avian mastocytoma","volume":"47","author":"Patnaik G. M.","year":"1970","journal-title":"Indian Veterinary Journal"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.3.81"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2000.0441"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-33.1.140"},{"key":"e_1_2_9_95_1","unstructured":"Reavill D. Fassler S. &Schmidt R.(2000).Mast cell tumor in a common iguana (Iguana iguana). Paper presented at: Association of Reptilian and Amphibian Veterinarians; Gainseville FL."},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.1257"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2015.07.006"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700416"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.03.006"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12246"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818800028"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15581205"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813476064"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814521638"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.11.004"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.04.002"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.2307\/30136923"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063879801000121"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.7589\/2015-07-182"},{"issue":"4","key":"e_1_2_9_110_1","first-page":"533","article-title":"Neoplasms and proliferative lesions in 1065 nonhuman primate necropsies","volume":"23","author":"Seibold H. R.","year":"1973","journal-title":"Laboratory Animal Science"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.10.005"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.b4861"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(05)80044-1"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589002700209"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.11.018"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12636"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043090"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10329-016-0579-2"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.9.2619.2619"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236870"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-731893"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870601800121"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.04.005"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2016.07.012"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05622"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14889"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.07.004"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300313"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2017-000533"},{"key":"e_1_2_9_130_1","volume-title":"Withrow and MacEwen's small animal clinical oncology","author":"Withrow S.","year":"2013"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.394"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02655.x"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-5-529"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.05.004"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142450"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T10:40:30Z","timestamp":1694083230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,24]]},"references-count":134,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/vms3.201"],"URL":"https:\/\/doi.org\/10.1002\/vms3.201","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,24]]},"assertion":[{"value":"2019-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}