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Local anaesthetic drugs used in local and regional blockade are unique in that they can completely block the transmission of pain (in conscious patients) or nociceptive (in anaesthetized patients) signals, thereby providing profound analgesia. In addition, local and regional administration of drugs, when compared with systemic bolus administration, generally results in a lower incidence of dose\u2010related adverse effects. Due to the potential to provide profound analgesia and the high safety margin (when used correctly) of this drug class, local anaesthetics are recommended as part of the analgesic protocol in the majority of patients undergoing surgical procedures or suffering traumatic injuries. This manuscript, Part 1 of a two\u2010part instalment, emphasizes the importance of using local and regional anaesthesia as a component of multimodal analgesia, provides a review of the basic pharmacokinetics\/pharmacodynamics of local anaesthetic drugs in general, lists information on commonly used local anaesthetic drugs for local and regional blockade in dogs and cats, and briefly introduces the novel liposome\u2010encapsulated bupivacaine (NOCITA\u00ae). Part 2 is a review of local and regional anaesthetic techniques used in dogs and cats (Grubb &amp; Lobprise, 2020).<\/jats:p>","DOI":"10.1002\/vms3.219","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T02:08:42Z","timestamp":1579658922000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Local and regional anaesthesia in dogs and cats: Overview of concepts and drugs (Part 1)"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-0279","authenticated-orcid":false,"given":"Tamara","family":"Grubb","sequence":"first","affiliation":[{"name":"Washington State University Pullman WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-4579","authenticated-orcid":false,"given":"Heidi","family":"Lobprise","sequence":"additional","affiliation":[{"name":"Main Street Veterinary Hospital Flower Mound TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X14533551"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny099"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP201775"},{"key":"e_1_2_5_5_1","volume-title":"France: The SOS Regional Anesthesia","author":"Auroy Y.","year":"2002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12318"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006-59.2.90"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15610162"},{"key":"e_1_2_5_9_1","first-page":"491","volume-title":"Anesthesia","author":"Berde C. 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