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The total of 288 1\u2010day\u2010old broilers were randomly allocated to four groups with six replications according to initial body weight. Four treatment groups were designed as follows and fed the indicated diets: CON, basal diet; T1, basal diet supplemented with 0.3\u00a0g\/kg SB; T2, basal diet supplemented with 0.6\u00a0g\/kg SB; T3, basal diet supplemented with 1.2\u00a0g\/kg SB. During days 1\u201321, broilers fed the T2 diet had higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) average daily gain (ADG) than broilers fed the CON diet. On day 21, dietary SB supplementation showed linear increase (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in relative weight of the duodenum, jejunum, ileum, small intestine (the sum weight of duodenum, jejunum and ileum), pancreas and thymus, and linear increase (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in relative length of the duodenum, jejunum, ileum, small intestine (the sum length of duodenum, jejunum and ileum) and caeca. Meanwhile, dietary SB supplementation showed linear increase in the antibody titer against ND on days 14, 21, 28 and 35. In conclusion, dietary SB supplementation improved the development of gastrointestinal by increasing the relative weight and length, as well as enhanced the immune response of ND vaccine.<\/jats:p>","DOI":"10.1002\/vms3.250","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T07:01:18Z","timestamp":1583218878000},"page":"491-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sodium butyrate as an effective feed additive to improve growth performance and gastrointestinal development in broilers"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4743-2612","authenticated-orcid":false,"given":"Rui Xia","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Animal Science College of Agriculture Guangdong Ocean University Zhanjiang Guangdong P.R. 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