{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:22Z","timestamp":1772118802202,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BK 21 Plus Program for Creative Veterinary Science Research","award":["5360-20150100"],"award-info":[{"award-number":["5360-20150100"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Four commercial porcine reproductive and respiratory syndrome virus (PRRSV) modified\u2010live vaccines (MLV) was compared to protect growing pigs against dual challenge of PRRSV\u20101 and PRRSV\u20102.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two of the vaccines were based on PRRSV\u20101, and two on PRRSV\u20102. A total of 72 PRRSV\u2010na\u00efve pigs were divided into six groups (12 pigs\/group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two PRRSV\u20101 MLV\u2010vaccinated and two PRRSV\u20102 MLV\u2010vaccinated groups reduced significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) genomic copies of PRRSV\u20101 in their sera compared to the unvaccinated challenged group. Two PRRSV\u20102 MLV\u2010vaccinated groups reduced significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) fewer genomic copies of PRRSV\u20102 in their sera whereas two PRRSV\u20101 MLV\u2010vaccinated groups were unable to reduce genomic copies of PRRSV\u20102 compared to unvaccinated challenged groups. Two PRRSV\u20101 MLV\u2010vaccinated groups induced a stronger PRRSV\u20101 specific IFN\u2010\u03b3\u2010SC response, while two PRRSV\u20102 MLV\u2010vaccinated groups induced a stronger PRRSV\u20102 specific IFN\u2010\u03b3\u2010SC response. Two PRRSV\u20102 MLV\u2010vaccinated groups showed significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) lower mean macroscopic and microscopic lung lesion scores compared to two PRRSV\u20101 MLV\u2010vaccinated groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data demonstrated that two PRRSV\u20102 vaccines were efficacious and exhibited similar protection while, two PRRSV\u20101 vaccines were largely ineffective against the dual challenge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.282","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T10:05:05Z","timestamp":1590055505000},"page":"846-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative evaluation of 4 commercial modified\u2010live porcine reproductive and respiratory syndrome virus (PRRSV) vaccines against heterologous dual Korean PRRSV\u20101 and PRRSV\u20102 challenge"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-5573","authenticated-orcid":false,"given":"Taehwan","family":"Oh","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University Gwanak\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University Gwanak\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejean","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University Gwanak\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyeon","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University Gwanak\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jin","family":"Ham","sequence":"additional","affiliation":[{"name":"College of Liberal Arts Anyang University Anyang\u2010si Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-1957","authenticated-orcid":false,"given":"Chanhee","family":"Chae","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National University Gwanak\u2010gu Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.669"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2015.03.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.103529"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.12.040"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.01.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589503200606"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2011.12.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.06.035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-45-12"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.07.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.11.039"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00001-15"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.022"},{"key":"e_1_2_9_15_1","first-page":"77","article-title":"Isolation of porcine reproductive and respiratory syndrome virus (PRRSV) in Korea","volume":"134","author":"Kweon C. 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