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Among other diagnostic tools, the seric CPSE has been studied and identified as a valid and specific biomarker for prostatic disorders, since it can result significantly more elevated in dogs affected by several prostatic abnormalities, such as benign prostatic hyperplasia, bacterial prostatitis and prostatic carcinoma. Therefore, dosing CPSE in serum represents a new diagnostic and screening tool. Dosing CPSE in everyday clinical practice has three objectives: (a) the diagnosis of benign prostatic hyperplasia; (b) the preventive screening of prostatic disorders in healthy dogs; (c) the medical follow\u2010up in subjects with prostatic disorders during and after medical therapy. Neither circadian rhythms nor transrectal palpation performed during the andrological examination do affect CPSE. A sexual rest of at least 24\u00a0hr before dosing CPSE is recommended as it is affected by ejaculation.<\/jats:p>","DOI":"10.1002\/vms3.349","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T22:53:15Z","timestamp":1599087195000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Highlights on the Canine Prostatic Specific Esterase (CPSE): A diagnostic and screening tool in veterinary andrology"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-1575","authenticated-orcid":false,"given":"Monica","family":"Melandri","sequence":"first","affiliation":[{"name":"Societ\u00e0 Veterinaria \u201cIl Melograno\u201d Srl Sesto Calende Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-150X","authenticated-orcid":false,"given":"Salvatore","family":"Alonge","sequence":"additional","affiliation":[{"name":"Societ\u00e0 Veterinaria \u201cIl Melograno\u201d Srl Sesto Calende Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2018.09.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13078"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13277"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13113"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10030381"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.1998.0267"},{"issue":"10","key":"e_1_2_11_9_1","first-page":"E1","article-title":"Canine prostatic carcinoma","volume":"34","author":"Axiak S. 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