{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:57:28Z","timestamp":1782734248400,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effect of prostaglandin and gonadotrophins (GnRH and hCG) combined with the ram effect on the progesterone (P4) concentrations and reproductive performance of Karakul ewes was investigated during non\u2010breeding season. Ewes (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a093) received a male effect and were divided into two treatment groups including GnRH \u2010 hCG (hCG,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a032), GnRH \u2010 GnRH (GnRH,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a030) and a control (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a031) group. This study was carried out from April (hormonal injection) to October (lambing). The first doses of GnRH (4.2\u00a0\u03bcg, Buserelin) were injected at the beginning of the study in treatment groups. These ewes were treated with hCG (250\u00a0IU) or the second GnRH dose five days later. All animals received two\u00a0injections (ten\u00a0days apart)\u00a0of 150\u00a0\u03bcg PGF2\u03b1\u00a0five days after the hCG or the second GnRH injection. Mating was initiated two days after the second prostaglandin injection and lasted for 34\u00a0days. Blood samples were collected by jugular venipuncture on days \u221210, \u22125, 0 (first PGF2\u03b1 injection), 17 and 30 during the study. Pregnancy diagnosis was performed through transabdominal ultrasonography on day 40 after the removing of ram. Conception rate was 93.8, 90 and 87.1% in the hCG, GnRH and control groups, respectively. Lambing rate tended to increase in the hCG group compared with the control group (87.1 versus 58.1%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.1). There was no significant difference in P4 concentrations among studied groups in identical sampling times (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u00a0.05). In conclusion, the administration of prostaglandin and hCG in combination with the ram effect tended to decrease lambing period. In other words this protocol tended to increase lambing rate at the first cycle. Treatment with hCG or GnRH did not increase serum P4 concentrations of treated Karakul ewes during the non\u2010breeding season.\n                  <\/jats:p>","DOI":"10.1002\/vms3.353","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T08:42:56Z","timestamp":1600591376000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effect of prostaglandin and gonadotrophins (GnRH and hCG) injection combined with the ram effect on progesterone concentrations and reproductive performance of Karakul ewes during the non\u2010breeding season"],"prefix":"10.1002","volume":"7","author":[{"given":"Mohammad","family":"Ayaseh","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences School of Veterinary Medicine Shiraz University Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-4211","authenticated-orcid":false,"given":"Abdolah","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences School of Veterinary Medicine Shiraz University Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alidad","family":"Boostani","sequence":"additional","affiliation":[{"name":"Department of Animal Science Research Fars Agricultural and Natural Resources Research and Education Center Agricultural Research, Education and Extension Organization (AREEO) Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansur","family":"Mehrvarz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences School of Veterinary Medicine Shiraz University Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2012.01.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2010.10.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09291016.2018.1548112"},{"key":"e_1_2_11_5_1","first-page":"28","article-title":"High twin lambing rate of synchronized ewes using progestagen combined with the gonadotropins injection in breeding season","volume":"167","author":"Ahmadi E.","year":"2016","journal-title":"Revue De M\u00e9decine V\u00e9t\u00e9rinaire"},{"key":"e_1_2_11_6_1","first-page":"34","article-title":"Efficacy of various synchronization protocols on the estrus behavior, lambing rate and prolificacy in rahmani egyptian ewes during the non\u2010breeding season","volume":"1","author":"Almadaly E.","year":"2016","journal-title":"Asian Journal of Animal and Veterinary Advances"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00288233.2005.9513681"},{"key":"e_1_2_11_8_1","first-page":"6","article-title":"Prevention of embryonic death using different hormonal treatments in ewes","volume":"37","author":"Ataman M. 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