{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:46:52Z","timestamp":1791931612169,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004493","name":"International Atomic Energy Agency","doi-asserted-by":"publisher","award":["RAS\/5\/060"],"award-info":[{"award-number":["RAS\/5\/060"]}],"id":[{"id":"10.13039\/501100004493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knowledge of sequential changes in haematobiochemical parameters of infected animals helps in the formulation of appropriate supportive therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the sequential haematological and biochemical changes in peste des petits ruminants (PPR)\u2010infected Black Bengal goats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Goats were either infected with PPR virus (PPRV;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08) or sham infected with sterile phosphate\u2010buffered saline (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04) via the intranasal route. Blood and sera were collected from both groups at different days post\u2010infection (dpi) and analysed. Goats were sacrificed at different dpi and the amount of PPRV RNA in different tissues was quantified by real\u2010time RT\u2010PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PPRV\u2010infected goats showed mild depression and scanty nasal secretions starting at 4 dpi which became severe with high fever (106\u00b0F), dyspnoea, stomatitis, profuse orinasal discharge and diarrhoea at 9\u201313 dpi. PPRV RNA was detected in different tissues of infected goats. Severe lymphocytic leukopenia (at 18 dpi) was observed in infected goats. Total protein and albumin decreased in infected goats starting at 10 dpi. An elevated level of enzymes (alkaline phosphatase, creatine kinase, aspartate transaminase and alanine transaminase) and metabolites (blood urea nitrogen and urea B) were found in infected goats starting at 7\u201310 dpi, suggesting damages in the liver and kidneys. PPR\u2010infected goats showed elevated sodium and chloride ions starting at 7 dpi. The majority of infected goats were seroconverted by 14 dpi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti\u2010diarrheal agents, aqua solutions and other medicine to support liver and kidney functions could be considered as supportive therapy against PPRV infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.373","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T09:36:02Z","timestamp":1601717762000},"page":"393-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sequential haematological and serum biochemical changes in Black Bengal goats infected with a local isolate of\n                    <i>peste des petits ruminants<\/i>\n                    virus from Bangladesh"],"prefix":"10.1002","volume":"7","author":[{"given":"Shahana","family":"Begum","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Nooruzzaman","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmary","family":"Hasnat","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-0628","authenticated-orcid":false,"given":"Mohammad Rafiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-7923","authenticated-orcid":false,"given":"Emdadul Haque","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Sustainable goat farming for livelihood improvement in Bangladesh: Opportunities, constrains and potential","author":"Ahmed S.","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-008-9178-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-4488(97)00095-3"},{"key":"e_1_2_9_5_1","volume-title":"Bangladesh Bureau of statistics","author":"BBS","year":"2019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4102\/ojvr.v85i1.1595"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-014-0247-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-014-0263-y"},{"issue":"9","key":"e_1_2_9_9_1","first-page":"19","article-title":"Haemato\u2010biochemical analysis of goats naturally infected with Peste Des Petits ruminants","volume":"2","author":"Das S.","year":"2015","journal-title":"International Journal for Research in Emerging Science and Technology"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12502"},{"issue":"3","key":"e_1_2_9_11_1","first-page":"710","article-title":"Hematological and biochemical alterations in goats due to paste des petits ruminant's viral infection","volume":"6","author":"Islam M.","year":"2018","journal-title":"Journal of Entomology and Zoology Studies"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"14","article-title":"An outbreak of peste des petits ruminants in Black Bengal Goats in Mymensngh, Bangladesh","volume":"18","author":"Islam M. R.","year":"2001","journal-title":"The Bangladesh Veterinarian"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"123","article-title":"Large scale outbreaks of Peste Des Petits ruminants in sheep and goats in Thar desert of India","volume":"44","author":"Kataria A.","year":"2007","journal-title":"Slovenian Veterinary Research"},{"key":"e_1_2_9_14_1","volume-title":"Laboratory manual of hematology and urinalysis","author":"Lamberg S. L.","year":"1978"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"11","article-title":"Haematological changes in natural and experimental peste des petits ruminants virus infection in goats","volume":"38","author":"Obi T. 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T.","year":"1988"},{"key":"e_1_2_9_20_1","first-page":"249","article-title":"Development of a N gene\u2010based PCR\u2010ELISA for detection of Peste\u2010des\u2010petits\u2010ruminants virus in clinical samples","volume":"48","author":"Saravanan P.","year":"2004","journal-title":"Acta Virologica"},{"issue":"2","key":"e_1_2_9_21_1","first-page":"322","article-title":"Studies on clinico\u2010haemato\u2010biochemical changes in peste des petits ruminants in goats","volume":"13","author":"Sharma C.","year":"2012","journal-title":"Veterinary Practitioner"},{"key":"e_1_2_9_22_1","volume-title":"Economic impact of transboundary animal diseases in SAARC countries","author":"Siddiky M. N. 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