{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:20:04Z","timestamp":1776122404237,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present prospective randomized experimental study was designed to determine the effects of doxapram on haematological, serum biochemical and antioxidant status in dogs after propofol anaesthesia. Twenty\u2010four healthy male mixed breed dogs, aged 1\u20132\u00a0years, weighing 20.4\u00a0\u00b1\u00a02.6\u00a0kg was studied. Each dog was anaesthetized twice, with at least one week for washout. Animals were sedated with acepromazine (0.1\u00a0mg\/kg) intramuscularly. Forty minutes later, anaesthesia was induced using intravenous (IV) propofol (4\u00a0mg\/kg) titration and maintained for 30\u00a0min by propofol (0.2\u00a0mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). After propofol was discontinued, doxapram (2\u00a0mg\/kg) hydrochloride was administrated IV in PD treatment while an equal volume of saline was administrated in PS treatment. Blood parameters were analysed in four times: immediately before sedation (T1), after treatment (T2), after complete recovery (T3) and 24\u00a0hr later (T4). Haematological assessments revealed no significant difference between treatments except in haematocrit which was significantly reduced at T4 (24\u00a0hr later) in PD. A decreasing trend of all haematological variables was observed after doxapram administration until recovery, except monocyte, mean corpuscular haemoglobin, red blood cell distribution width and platelet count. Serum urea, creatinine, glucose, cholesterol, direct bilirubin concentration and alanine aminotransferase activity were not changed following doxapram administration compared to the PS treatment. After doxapram administration, Creatinine (T3), Albumin (T2) and Protein (T2 &amp; T3) decreased while Glucose (T2 &amp; T3) and BT (T3) increased. Antioxidant parameters measured showed no difference between treatments or time. Doxapram (2\u00a0mg\/kg) IV did not induce any major negative effects on haematological, serum biochemical variables and oxidant\/antioxidant status in dogs after propofol anaesthesia.\n                  <\/jats:p>","DOI":"10.1002\/vms3.398","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T02:50:49Z","timestamp":1605754249000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effects of doxapram on haematology, serum biochemical parameters and erythrocyte oxidant\/ antioxidant status in dogs anaesthetized with propofol"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-9933","authenticated-orcid":false,"given":"Soroush","family":"Sabiza","sequence":"first","affiliation":[{"name":"Departement of clinical sciences Faculty of veterinary medicine Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Naddaf","sequence":"additional","affiliation":[{"name":"Departement of clinical sciences Faculty of veterinary medicine Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-5974","authenticated-orcid":false,"given":"Seyedeh Misagh","family":"Jalali","sequence":"additional","affiliation":[{"name":"Departement of clinical sciences Faculty of veterinary medicine Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Baniadam","sequence":"additional","affiliation":[{"name":"Departement of clinical sciences Faculty of veterinary medicine Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahman","family":"Mosallanejad","sequence":"additional","affiliation":[{"name":"Departement of clinical sciences Faculty of veterinary medicine Shahid Chamran University of Ahvaz Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Aglia D. 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