{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:44Z","timestamp":1772118944694,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002449","name":"Jeju National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phenobarbital\u2010responsive sialadenosis (PRS) can cause nausea and vomiting, and is rarely reported in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>An 8\u2010year\u2010old neutered, male Pomeranian dog was presented to our teaching hospital with vomiting that began 2\u00a0years ago. The clinical signs repeatedly improved and deteriorated despite treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The only abnormality found on physical examination was salivary gland enlargement, and no specific findings were observed on blood analysis and imaging tests. The results of the fine needle aspirate cytology from the salivary glands revealed possible sialadenosis. Phenobarbital was prescribed, and the patient's symptoms resolved. However, upon discontinuing drug, the patient's clinical signs recurred and did not improve even after re\u2010introduction of phenobarbital and the addition of other anticonvulsant drugs. An oesophageal stricture was observed on an oesophagram, and fibrosis was confirmed endoscopically. A balloon dilation was performed to expand the stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After the first procedure, the patient's clinical signs initially improved, but relapsed 2\u00a0weeks later. A total of three oesophageal dilation procedures were performed using a sequentially larger diameter balloon. After the third procedure, the patient's clinical signs were managed without recurrence. The cause of recurrent gastrointestinal signs following the initial successful treatment of phenobarbital\u2010responsive sialadenosis was due to oesophageal stricture formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case report demonstrates the successful management of PRS with subsequent oesophageal stricture formation in a dog.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.416","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T13:40:08Z","timestamp":1610286008000},"page":"660-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of a dog with phenobarbital\u2010responsive sialadenosis and an oesophageal stricture"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-9460","authenticated-orcid":false,"given":"Hyung\u2010Kyu","family":"Chae","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Cheol","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and the Research Institute for Veterinary Science Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-551X","authenticated-orcid":false,"given":"Woo\u2010Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine and Research Institute of Veterinary Medicine College of Veterinary Medicine Jeju National University Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-1348","authenticated-orcid":false,"given":"Hwa\u2010Young","family":"Youn","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"55","article-title":"Benign esophageal stricture in the dog and cat: A retrospective study of 20 cases","volume":"66","author":"Adamama\u2010Moraitou K. 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