{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:20:49Z","timestamp":1790403649656,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recombinant lysostaphin has been used for the treatment of cow endometritis and mastitis in China. To our knowledge, no scientific effort has been made to evaluate the efficacy of lysostaphin in sows with clinical endometritis. Lysostaphin, loaded in effervescent tablets that were completely foamed and dissolved within 30\u00a0min in the presence of water or body fluids and released active lysostaphin, were administered vaginally on endometritis sows in this study. The clinical recovery, bacterial clearance and reproductive performance of sows with endometritis were investigated. We found that the 400U dosage (400U lysostaphin\/pill\/time, repeat once on the third day, a total of two times, with 10% oxytetracycline uterine injection as a control) is the most effective treatment.\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    was the most prevalent finding (34%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0188), followed by\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (32%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0181),\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (19%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0104) and other bacilli (15%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a083) before treatment by drugs. Administration of lysostaphin resulted in an extremely significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01) reduction in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (0.18\u00a0\u00b1\u00a00.25 from 4.57\u00a0\u00b1\u00a00.33) and\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (0.11\u00a0\u00b1\u00a00.14 from 3.88\u00a0\u00b1\u00a00.29), as well as a significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) reduction in\n                    <jats:italic>E. coli<\/jats:italic>\n                    (0.55\u00a0\u00b1\u00a00.42 from 3.11\u00a0\u00b1\u00a00.14). Mixed infections (83%) were predominant before treatment, in contrast to single infections (61%) after treatment. Large\u2010scale trials were conducted to verify the clinical efficacy of lysostaphin on sow endometritis. The average cure rate of 400u lysostaphin on sow endometritis(82.5%) was higher than the antibiotic group(72.17%). In addition, our results revealed that intravaginal administration of lysostaphin had no adverse effect on the reproductive performance of sows. Thus, this lysostaphin has potential application value as a new method alternative to antibiotics to treat endometritis in sows.\n                  <\/jats:p>","DOI":"10.1002\/vms3.417","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T15:49:29Z","timestamp":1609688969000},"page":"746-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical efficacy of intravaginal recombinant lysostaphin administration on endometritis in sows"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1576-0128","authenticated-orcid":false,"given":"Guizi","family":"Ye","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai P.R.China"},{"name":"Kunshan Bio\u2010Green Biotechnology Co., Ltd Kunshan P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Kunshan Bio\u2010Green Biotechnology Co., Ltd Kunshan P.R.China"},{"name":"Shanghai High\u2010Tech United Bio\u2010Technological R&amp;D Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai High\u2010Tech United Bio\u2010Technological R&amp;D Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jien","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai High\u2010Tech United Bio\u2010Technological R&amp;D Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxue","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology South China Agricultural University Guangzhou P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pharmacology South China Agricultural University Guangzhou P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Bao","sequence":"additional","affiliation":[{"name":"Yangzhou University Yangzhou P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshan","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101219"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.12.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2010.509363"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4320(92)90091-Q"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.01.016"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"63","article-title":"UROGENITAL INFECTIONS OF SWINE.1. 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