{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:16:29Z","timestamp":1772118989383,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Occult (or atypical) hyperadrenocorticism (HAC) shows clinical signs and laboratory abnormalities similar to classic hyperadrenocorticism, but normal signs in routine screening tests such as the corticotropin (ACTH) stimulation test and low\u2010dose dexamethasone suppression test (LDDST). Here, we describe a case of occult HAC in a Yorkshire terrier treated with mitotane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>An 11\u2010year\u2010old spayed female presented to the Veterinary Teaching Hospital of Seoul National University because of respiratory distress symptoms, polyphagia, and polydipsia, suggestive of HAC. In abdominal sonography, enlargement of the caudal pole of the left adrenal gland was found, but the cortisol level of post\u2010ACTH stimulation test was below the cut\u2010off value, and LDDST was negative. To finalise the diagnosis of occult HAC, 17\u2010hydroxyprogesterone (17\u2010OHP) was examined. The concentrations of 17\u2010OHP (pre\u2010 and post\u2010ACTH stimulation) were found to be elevated. As occult HAC was highly suspected, we prescribed trilostane for trial therapy. At first, the clinical signs improved, but they later worsened. We changed medication as trilostane to mitotane, and the symptoms were relieved after mitotane administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is a unique case of occult HAC in which the response to mitotane was better than trilostane.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.482","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T07:45:50Z","timestamp":1616485550000},"page":"1150-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful treatment of occult hyperadrenocorticism with mitotane but not trilostane in a dog"],"prefix":"10.1002","volume":"7","author":[{"given":"Su\u2010Min","family":"Park","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong\u2010Bo","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-551X","authenticated-orcid":false,"given":"Woo\u2010Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine College of Veterinary Medicine Jeju National University Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-1348","authenticated-orcid":false,"given":"Hwa\u2010Young","family":"Youn","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine Department of Veterinary Clinical Science College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2009.11.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12192"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1095"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.105343"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0479"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2017.03.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.02.002"},{"key":"e_1_2_9_9_1","first-page":"400","article-title":"Atypical Cushing's syndrome associated with sex steroids excess in a dog","volume":"29","author":"Kim J.\u2010H.","year":"2012","journal-title":"Journal of Veterinary Clinics"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2225-x"},{"key":"e_1_2_9_11_1","volume-title":"Small animal internal medicine","author":"Nelson R. W.","year":"2014"},{"key":"e_1_2_9_12_1","first-page":"471","volume-title":"Proc 25th Ann Vet Med Forum","author":"Oliver J.","year":"2007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb01261.x"},{"key":"e_1_2_9_14_1","first-page":"219","volume-title":"Kirk's current veterinary therapy XIV","author":"Scott\u2010Moncrieff J.","year":"2009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.1725"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:53:56Z","timestamp":1693295636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/vms3.482"],"URL":"https:\/\/doi.org\/10.1002\/vms3.482","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.482\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.482\/v2\/review1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}