{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:34:42Z","timestamp":1792629282655,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872520"],"award-info":[{"award-number":["31872520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aloe vera is reputed to have medicinal properties. For centuries, it has been used for an array of ailments such as mild fever, wounds and burns, gastrointestinal disorders, diabetes, sexual vitality and fertility problems to cancer, immune modulation, AIDS and various skin infections. In present study, antibacterial activity of aloe vera gel extracts was tested against some common skin infection pathogens, that is,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Shigella, Salmonella<\/jats:italic>\n                    spp. and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    all were recorded positive. Antibiotic resistance and susceptibility pattern of above isolates were also studied against 10 clinically significant antibiotics (ampicillin [AMC], amoxicillin, augmentin, cefotaxime, ceftazidime [CAZ], cefuroxime [CXM], ciprofloxaci, tetracycline, cefpodoxime and imipenem). AMC and CXM were found to be most effective antibiotic followed by CXM with highest efficacy against Gram\u2010negative bacteria. In case of CAZ showed highest efficacy was showed against Gram\u2010positive bacteria. Aloe vera leave gel was extracted with four different solvent\u2010like aloe vera leaf extract, root extract, leaf ethanol extract and root ethanol extract; however, Gram\u2010negative as well Gram\u2010positive isolates was found highest susceptibility with aloe leaf and aloe root ethanol extract. Moderate sensitivity observed with aloe leaf extract and aloe root extract against both Gram\u2010positive as well as Gram\u2010negative bacterial isolates. This result showed that ethanol extracts of aloe vera both leaf and root can be used alongside conventional antibiotics to fight agents of infections that are so prevalent in the skin infection.\n                  <\/jats:p>","DOI":"10.1002\/vms3.488","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T06:46:24Z","timestamp":1620197184000},"page":"2061-2067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Comparative study of antimicrobial action of aloe vera and antibiotics against different bacterial isolates from skin infection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-9708","authenticated-orcid":false,"given":"Safia","family":"Arbab","sequence":"first","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development Ministry of Agriculture  Lanzhou China"},{"name":"Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanif","family":"Ullah","sequence":"additional","affiliation":[{"name":"Key Laboratory of New Animal Drug Project of Gansu Province  Lanzhou China"},{"name":"Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Weiwei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development Ministry of Agriculture  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development Ministry of Agriculture  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah Uddin","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development Ministry of Agriculture  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development Ministry of Agriculture  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Veterinary Pharmaceutical Development Ministry of Agriculture  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB2005.000-3114"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.17582\/journal.pjz\/20190424140406"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.19045\/bspab.2021.100114"},{"key":"e_1_2_11_5_1","first-page":"3835","article-title":"Comparative study of antimicrobial activities of Aloe vera extracts and antibiotics against isolates from skin infections","volume":"10","author":"Bashir A.","year":"2011","journal-title":"African Journal of Biotechnology"},{"key":"e_1_2_11_6_1","first-page":"1058","article-title":"Comparative study of antimicrobial activity of Aloe vera gel and antibiotics against isolates from fast food","volume":"4","author":"Chatterjee R.","year":"2015","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-752X.2006.00155.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765X.2002.01109.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.15272\/ajbps.v4i35.564"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.778-780.2006"},{"key":"e_1_2_11_11_1","first-page":"45","article-title":"In vitro antimicrobial activity and phytochemical screening of Aloe vera Linn","volume":"4","author":"Kumar H. K.","year":"2012","journal-title":"International Journal of Current Pharmaceutical Research"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00107-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2003.01626.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4506.2000.tb00014.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04351.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2005.04.013"},{"key":"e_1_2_11_17_1","article-title":"Bacteriological studies on surgical and non\u2010surgical wounds located on body surface of animals","author":"Rind R.","year":"2000","journal-title":"Pakistan Journal of Biological Sciences (Pakistan)"},{"key":"e_1_2_11_18_1","first-page":"1058","article-title":"Comparative study of antimicrobial activity of Aloe vera gel and antibiotics against isolates from fast food","volume":"4","author":"Rudrangshu C.","year":"2015","journal-title":"World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)"},{"key":"e_1_2_11_19_1","first-page":"24","article-title":"Natural products as aids for protecting the skin's immune system against UV damage","volume":"74","author":"Strickland F. 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