{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:48:05Z","timestamp":1778953685072,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31760305"],"award-info":[{"award-number":["31760305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The telencephalon is also known as the cerebrum, and it consists of the largest part of the brain. It makes up about 85% of the total weight of the brain. Neuroglobin (Ngb) is a protein found in neurons of both the peripheral and central nervous system that appears to convey some resilience to hypoxia, while the hypoxia\u2010inducible factor (Hif\u20101\u03b1) is a dimeric protein complex that plays an integral role in the body's response to low oxygen concentrations, or hypoxia. The study examines the expression of Ngb and Hif\u20101\u03b1 in the telencephalon of adult yak in the telencephalon. The immunohistochemistry (IHC), quantitative real\u2010time PCR and Western blot (WB) were employed to investigate Ngb and Hif\u20101\u03b1 expression in the telencephalon. Ngb and Hif\u20101\u03b1 are significantly expressed in all tissues of the telencephalon except the hypothalamus. The cerebellar cortex, hippocampus, amygdala, cerebellum and corpus callosum recorded the highest expression but not significant. The overall expression revealed that Ngb expression was higher as compared to Hif\u20101\u03b1. The IHC results also showed that the expression of Ngb and Hif\u20101\u03b1 were higher in the cerebellar cortex, hippocampus, amygdala, cerebellum and corpus callosum as compared to other regions. The results suggested that Ngb and Hif\u20101\u03b1 expression influence the adaptive mechanism of yak to the high altitude environment. Both Ngb and Hif\u20101\u03b1 participate in oxygen transports throughout the telencephalon and have functions in neuroprotection. Further studies are needed to confirm the mechanism of adaptation.<\/jats:p>","DOI":"10.1002\/vms3.553","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T09:37:06Z","timestamp":1624095426000},"page":"1707-1717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression and distribution of neuroglobin and hypoxia\u2010inducible factor\u20101\u03b1 in the adult yak telencephalon"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-6860","authenticated-orcid":false,"given":"Xiaohua","family":"Du","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Gansu Agricultural University  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-8101","authenticated-orcid":false,"given":"James Blackar","family":"Mawolo","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Gansu Agricultural University  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Gansu Agricultural University  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Mi","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Gansu Agricultural University  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Gansu Agricultural University  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Gansu Agricultural University  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015379107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.01.080"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408766102"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35035093"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1166-x"},{"key":"e_1_2_12_7_1","first-page":"1145","article-title":"A viral vector expressing hypoxia\u2010inducible factor 1 alpha inhibits hippocampal neuronal apoptosis","volume":"11","author":"Chai X.","year":"2014","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_12_8_1","first-page":"1803","article-title":"Changes of hypoxia\u2010inducible factor\u20101 signaling and the effect of cilostazol in chronic cerebral ischemia","volume":"19","author":"Chen H.","year":"2013","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6360"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0480-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00154-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21002"},{"key":"e_1_2_12_13_1","first-page":"146","article-title":"Protection by neuroglobin expression in brain pathologies","volume":"7","author":"Eliana B.","year":"2016","journal-title":"Frontiers in Neurology"},{"issue":"16","key":"e_1_2_12_14_1","first-page":"30357","article-title":"A critical re\u2010evaluation of neuroglobin expression reveals conserved patterns among mammals","volume":"0306","author":"Fabrizius A.","year":"2016","journal-title":"Neuroscience"},{"key":"e_1_2_12_15_1","volume-title":"Hypoxia\u2010inducible factor in the brain","author":"Frank R. 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