{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:37:01Z","timestamp":1776501421306,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009587","name":"School of Veterinary Science, Shiraz University","doi-asserted-by":"publisher","award":["94GCU2M163773"],"award-info":[{"award-number":["94GCU2M163773"]}],"id":[{"id":"10.13039\/100009587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Septic arthritis (SA) due to <jats:italic>Staphylococcus aureus<\/jats:italic> is a major cause of lameness in poultry with improper response to antimicrobial therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study evaluates the effect of prophylactic administration of vitamin C on SA induced by methicillin resistant <jats:italic>S. aureus<\/jats:italic> in chickens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty chickens were randomly assigned into four groups: I. Negative control (NC), II. Positive control (PC) with SA induced at the age of 35 days by intra articular injection of <jats:italic>S. aureus<\/jats:italic>. III. Vehicle control (VC) and IV. Arthritic vitamin C\u2010treated (VitC) group (15\u00a0g\/100 L of drinking water from day 25 to the end of the experiment). Samplings were performed on day 44 (sampling 1) and day 54 (sampling 2) of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arthritic birds showed an obvious decrease in body weight with severe clinical arthritis and lameness which were not significantly affected by vitamin C administration at both samplings. Moreover, marked increase in serum malondialdehyde (MDA) concentration of the PC group was observed in sampling 1. Administration of vitamin C successfully reduced MDA concentration at both samplings. In sampling 2, birds in the VitC group showed significantly higher total antioxidant capacity (TAC) than NC birds (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Interleukin\u20106 concentration in synovial fluid of chickens remained statistically similar among groups in both samplings, while histopathological changes were ameliorated in the VitC group in sampling 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylactic administration of vitamin C especially for relatively longer period can ameliorate oxidative stress and histopathological changes due to staphylococcal arthritis in chickens, although it is not associated with a significant effect on clinical manifestations of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.649","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T22:05:59Z","timestamp":1633039559000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of prophylactic administration of vitamin C in chickens with staphylococcal septic arthritis"],"prefix":"10.1002","volume":"8","author":[{"given":"Fahimeh","family":"Nematollahi","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-7815","authenticated-orcid":false,"given":"Tahoora","family":"Shomali","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahman","family":"Abdi\u2010Hachesoo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdollah","family":"Derakhshandeh","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azizollah","family":"Khodakaram\u2010Tafti","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam Sadat","family":"Moezzi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine Shiraz University  Shiraz 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