{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:04:49Z","timestamp":1793077489010,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This field trial was designed to evaluate the efficacy of a new trivalent vaccine containing porcine circovirus type 2a and 2b (PCV2a\/b), and\n                      <jats:italic>Mycoplasma hyopneumoniae<\/jats:italic>\n                      at three independent locations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Three farms were selected based on their history of PCV2 and\n                      <jats:italic>M. hyopneumoniae<\/jats:italic>\n                      co\u2010infection. Each farm housed a total of 60, 3\u2010day\u2010old pigs that were randomly allocated to one of three treatment groups. Pigs were administered the trivalent vaccine intramuscularly with either a 1.0\u00a0ml dose at 3 and 24 days of age or a 2.0\u00a0ml dose at 21 days of age in accordance with the manufacturer's recommendations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinically, the average daily weight gain of the one\u2010dose and two\u2010dose vaccinated groups within all three farms was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) than those of unvaccinated animals during the growing (70\u2013112 days of age), finishing (112\u2013175 days of age) and overall (3\u2013175 days of age) stages of production. One\u2010dose and two\u2010dose vaccinated animals elicited neutralizing antibodies and interferon\u2010\u03b3\u2010secreting cells (IFN\u2010\u03b3\u2010SC), which reduced the amount of PCV2 in terms of blood load and reduced the severity of lymphoid lesions when compared with unvaccinated animals. Similarly, one\u2010dose and two\u2010dose vaccinated animals elicited IFN\u2010\u03b3\u2010SC, which reduced the amount of\n                      <jats:italic>M. hyopneumoniae<\/jats:italic>\n                      in terms of laryngeal load and reduced the severity of lung lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The intramuscular administration of either one or two doses of trivalent vaccine was not significantly different in any of the evaluated parameters. The results of field trial demonstrated that the trivalent vaccine was efficacious in the protection of swine herds where PCV2d and\n                      <jats:italic>M. hyopneumoniae<\/jats:italic>\n                      were in active circulation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.657","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T23:40:35Z","timestamp":1634946035000},"page":"578-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A field efficacy trial of a trivalent vaccine containing porcine circovirus type 2a and 2b, and\n                    <i>Mycoplasma hyopneumoniae<\/i>\n                    in three herds"],"prefix":"10.1002","volume":"8","author":[{"given":"Hyungmin","family":"Um","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Pathology Seoul National 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