{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:20:28Z","timestamp":1774279228484,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), besides causing human infection, has been shown to naturally infect several susceptible animal species including large cats (tigers, lions, pumas, spotted leopards), dogs, cats, ferrets, gorillas and minks. Cats and minks are continuing to be the most reported species with SARS\u2010CoV\u20102 infections among animals but it needs to be investigated further.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We report the detection of SARS\u2010CoV\u20102 from a domestic cat that exhibited respiratory disease after being exposed to SARS\u2010CoV\u20102 virus from humans in the same household. SARS\u2010CoV\u20102 RNA was detected in two oropharyngeal swabs collected at two time points, 11 days apart; the first, when the cat was reported to be sick and the second, before euthanasia due to poor prognosis. The viral nucleic acid detected at two time points showed no genomic variation and resembled the clade GH circulating in humans in the United States. Clinical and pathological findings noted in this 16\u2010year\u2010old cat were consistent with respiratory and cardiac insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SARS\u2010CoV\u20102 viral infection was likely an incidental clinical finding, as the virus was not detected in\u00a0fixed lungs, heart, or kidney tissues. Only fresh lung tissue collected at necropsy showed the presence of viral nucleic acid, albeit at a very low level. Further research is needed to clarify the\u00a0clinical course of SARS\u2010CoV\u20102 in companion animals of advanced age and underlying cardiac disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.695","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T09:59:42Z","timestamp":1639562382000},"page":"899-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transmission of SARS\u2010CoV\u20102 from humans to a 16\u2010year\u2010old domestic cat with comorbidities in Pennsylvania, USA"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-3026","authenticated-orcid":false,"given":"Deepanker","family":"Tewari","sequence":"first","affiliation":[{"name":"Pennsylvania Department of Agriculture Pennsylvania Veterinary Laboratory  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lore","family":"Boger","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Agriculture Pennsylvania Veterinary Laboratory  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Brady","sequence":"additional","affiliation":[{"name":"Silver Spring Clinic  Palmyra Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Livengood","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Agriculture Pennsylvania Veterinary Laboratory  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Lea","family":"Killian","sequence":"additional","affiliation":[{"name":"Diagnostic Virology Laboratory National Veterinary Services Laboratories  Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera Surendran","family":"Nair","sequence":"additional","affiliation":[{"name":"Animal Diagnostic Laboratory Pennsylvania State University  State College Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaraja","family":"Thirumalapura","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Agriculture Pennsylvania Veterinary Laboratory  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-254X","authenticated-orcid":false,"given":"Suresh V.","family":"Kuchipudi","sequence":"additional","affiliation":[{"name":"Animal Diagnostic Laboratory Pennsylvania State University  State College Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"Zellers","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Agriculture Pennsylvania Veterinary Laboratory  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Schroder","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Health Bureau of Epidemiology  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Torchetti","sequence":"additional","affiliation":[{"name":"Diagnostic Virology Laboratory National Veterinary Services Laboratories  Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-2726","authenticated-orcid":false,"given":"Ann","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Centers for Disease Control  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Centers for Disease Control  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Brightbill","sequence":"additional","affiliation":[{"name":"Pennsylvania Department of Agriculture Pennsylvania Veterinary Laboratory  Harrisburg Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.552909"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2612.202786"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"Bosco\u2010Lauth A. M. Hartwig A. E. Porter S. M. Gordy P. W. Nehring M. Byas A. D. VandeWoude S. Ragan I. K. Maison R. M. &Bowen R. A.(2020).Pathogenesis transmission and response to re\u2010exposure of SARS\u2010CoV\u20102 in domestic cats.bioRxiv2020.05.28.120998.","DOI":"10.1101\/2020.05.28.120998"},{"key":"e_1_2_9_5_1","unstructured":"CDC. (2021). Pets and other animals.https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/animals\/pets\u2010other\u2010animals.html"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.259.9.1032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00514"},{"key":"e_1_2_9_8_1","article-title":"Detection of 2019 novel coronavirus (2019\u2010nCoV) by real\u2010time RT\u2010PCR","volume":"25","author":"Corman V. 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