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Each farm housed a total of 40, 18\u2010day\u2010old pigs that were randomly allocated to 1 of 2 treatment groups. Pigs were administered a 2.0\u00a0mL dose of the bivalent vaccine intramuscularly at 21 days of age in accordance with the manufacturer's recommendations, whereas unvaccinated pigs were administered a single dose of phosphate\u2010buffered saline at the same age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinically, the average daily weight gain of vaccinated groups was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) than those of unvaccinated animals during the growing (70\u2013112 days of age), finishing (112\u2013175 days of age) and overall (3\u2013175 days of age) stages of production. Vaccinated animals elicited neutralizing anti\u2010PCV2 antibodies and PCV2d\u2010specific interferon\u2010\u03b3 secreting cells (IFN\u2010\u03b3\u2010SC), which reduced the amount of PCV2d genomic copies in blood and reduced lymphoid lesions severity when compared with unvaccinated animals. Similarly, vaccinated animals elicited\n                      <jats:italic>M. hyopneumoniae<\/jats:italic>\n                      \u2010specific IFN\u2010\u03b3\u2010SC, which reduced the amount of\n                      <jats:italic>M. hyopneumoniae<\/jats:italic>\n                      in the larynx and reduced lung lesions severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The result of the field trial demonstrated that the bivalent vaccine was efficacious in the protection of swine herds suffering from subclinical PCV2d infection and enzootic pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70001","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T09:29:09Z","timestamp":1724750949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A field evaluation of a new porcine circovirus type 2d and\n                    <i>Mycoplasma hyopneumoniae<\/i>\n                    bivalent vaccine in herds suffering from subclinical PCV2d infection and enzootic pneumonia"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-5597","authenticated-orcid":false,"given":"Sehyeong","family":"Ham","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-911X","authenticated-orcid":false,"given":"Jeongmin","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonghan","family":"Kim","sequence":"additional","affiliation":[{"name":"WOOGENE B&amp;G CO., LTD.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung\u2010Joo","family":"Seo","sequence":"additional","affiliation":[{"name":"WOOGENE B&amp;G CO., LTD.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong\u2010Seo","family":"Park","sequence":"additional","affiliation":[{"name":"WOOGENE B&amp;G CO., LTD.  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