{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:26:42Z","timestamp":1777116402103,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to determine the effects of dietary supplementation of arginine (ARG) or guanidinoacetic acid (GAA), with or without phenylalanine (PHE), on the ascites susceptibility in the cold\u2010stressed broilers fed canola meal (CM)\u2010based diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 450 one\u2010day\u2010old male broiler chicks were randomly allocated to 30 floor pens with 6 replications for each of the 5 treatments. The dietary treatments were as follows: CM\u2010based diet (control), CM\u2010based diet\u00a0+\u00a02.57\u00a0g\/kg ARG, CM\u2010based diet\u00a0+\u00a01.8\u00a0g\/kg GAA, CM\u2010based diet\u00a0+\u00a02.57\u00a0g\/kg ARG\u00a0+\u00a01.5\u00a0g\/kg PHE and CM\u2010based diet\u00a0+\u00a01.8\u00a0g\/kg GAA\u00a0+\u00a01.5\u00a0g\/kg PHE. The groups experienced cold stress induction starting at 32\u00b0C on day one, with gradual reductions to 15\u00b0C on days 21. The temperature was then held at 15\u00b0C for the remainder of the experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The supplements ARG\u00a0+\u00a0PHE and GAA\u00a0+\u00a0PHE resulted in improved feed conversion ratios (FCR) when compared to the control group. In comparison with the control group, supplementation of ARG and ARG\u00a0+\u00a0PHE decreased the ascites mortality by increasing the plasma nitric oxide level (NO), blood O\n                      <jats:sub>2<\/jats:sub>\n                      partial pressure, blood O\n                      <jats:sub>2<\/jats:sub>\n                      saturation (SO\n                      <jats:sub>2<\/jats:sub>\n                      ), and decreasing the blood CO\n                      <jats:sub>2<\/jats:sub>\n                      partial pressure (PCO\n                      <jats:sub>2<\/jats:sub>\n                      ) and right ventricle to total ventricle (RV:TV) ratio. Supplementation of GAA and GAA\u00a0+\u00a0PHE also declined ascites mortality by reducing blood PCO\n                      <jats:sub>2<\/jats:sub>\n                      while increasing blood SO\n                      <jats:sub>2<\/jats:sub>\n                      and plasma NO levels. Although plasma corticosterone level and RV:TV ratio were similar between the GAA and control groups, adding GAA\u00a0+\u00a0PHE significantly reduced both compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, supplementing cold\u2010stressed broiler chicken diets with 2.57\u00a0g\/kg ARG may alleviate hypertension. Additionally, 1.8\u00a0g\/kg GAA proves to be an effective substitute for dietary ARG in low\u2010ARG diets, alleviating adverse effects from cold stress. Proper PHE formulation, at 1.5\u00a0g\/kg in this study, is crucial when using ARG and GAA supplements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70011","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T07:54:13Z","timestamp":1728114853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Attenuating susceptibility to ascites in cold\u2010stressed broiler chickens fed canola meal\u2010based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-3104","authenticated-orcid":false,"given":"Negin","family":"Delfani","sequence":"first","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture Urmia University  Urmia 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