{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:51:30Z","timestamp":1788861090447,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007860","name":"Ilam University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Phytogenic additives would be helpful to alleviate the adverse effect of\n                      <jats:italic>Campylobacter jejuni<\/jats:italic>\n                      on the performance and physiological responses of broiler chickens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This experiment was carried out to investigate the effects of\n                      <jats:italic>Echinacea purpurea<\/jats:italic>\n                      (\n                      <jats:bold>EP<\/jats:bold>\n                      ) and\n                      <jats:italic>Thymbra spicata<\/jats:italic>\n                      (\n                      <jats:bold>TS<\/jats:bold>\n                      ) on the performance, nutrient digestibility, serum biochemistry, intestinal morphology, intestinal microbiota and immune responses of broilers challenged with\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      from 0 to 42 days of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 240 male broiler chickens were divided into 6 groups and fed various diets: a control diet; the control diet supplemented with EP at 0.25% (EP25) or 0.50% (EP50); the control diet supplemented with TS at 0.25% (TS25) and 0.50% (TS50); or the control diet containing erythromycin at 55\u00a0ppm. Chicks were orally challenged with\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      on Days 21 and 23 of age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EP and TS25 diets enhanced European production efficiency factor, feed conversion ratio and digestibility of dry matter and organic matter. TS25 increased duodenal villous height (VH) and surface area on Day 42 of age. EP25 diet increased ileal VH compared to control and erythromycin diets. Diets containing certain EP25 and TS increased the\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      population and decreased\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      population on Day 39 of age. EP50 and TS50 diets increased antibody titration against Newcastle disease virus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In conclusion, EP and TS dietary supplementation improved performance, microflora, intestinal morphology and immune responses in\n                      <jats:italic>C. jejuni<\/jats:italic>\n                      \u2010challenged broilers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70028","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T07:53:35Z","timestamp":1726041215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of dietary medicinal plants on physiological responses of broiler chickens challenged with\n                    <i>Campylobacter jejuni<\/i>"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6259-2766","authenticated-orcid":false,"given":"Zaynab","family":"Nazari","sequence":"first","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture Ilam University  Ilam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-5392","authenticated-orcid":false,"given":"Hassan","family":"Shirzadi","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture Ilam University  Ilam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-7904","authenticated-orcid":false,"given":"Kamran","family":"Taherpour","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture Ilam University  Ilam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8054-1541","authenticated-orcid":false,"given":"Enayat","family":"Rahmatnejad","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture and Natural Resources Persian Gulf University  Bushehr Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-8146","authenticated-orcid":false,"given":"Ali","family":"Khatibjoo","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture Ilam University  Ilam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/1592708"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010003\u20100938\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8020087"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2016.1245594"},{"issue":"12","key":"e_1_2_11_6_1","first-page":"7595","article-title":"Determination of chemical compositions, antifungal, antibacterial and antioxidant activity of Thymbra spicata L. from Turkey","volume":"26","author":"Bayan Y.","year":"2017","journal-title":"Fresenius Environmental Bulletin"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex308"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2008.07.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010018\u20100477\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2011.559454"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2005.12.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3906\/vet\u20101502\u201068"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"23","article-title":"Performance, immunity, and serum biochemical parameters in broiler chickens fed diet supplemented with Zataria multiflora essential oil","volume":"3","author":"Ghazvinian K.","year":"2017","journal-title":"Advanced Herbal Medicine"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopen.2017.02.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2012\u201002685"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/83.2.169"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01364\u201014"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09712119.2015.1091344"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2017.09.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3522"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3382\/japr.2011\u201000369"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100396.2005.00501.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2015.05.021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.12.030"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09712119.2011.565555"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/66273\/2010"},{"issue":"4","key":"e_1_2_11_27_1","first-page":"363","article-title":"Immune response to and histopathology of Campylobacter jejuni infection in ferrets (Mustela putorius furo)","volume":"59","author":"Nemelka K. W.","year":"2009","journal-title":"Comparative Medicine"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pey339"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3382\/japr\/pfw073"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aaspro.2016.09.064"},{"key":"e_1_2_11_31_1","first-page":"527","article-title":"Effect of the three herbal extracts on growth performance, immune system, blood factors and intestinal selected bacterial population in broiler chickens","volume":"13","author":"Rahimi S.","year":"2011","journal-title":"Journal of Agricultural Science and Technology"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2005.12.007"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.5455\/japa.20150118041009"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5937"},{"issue":"4","key":"e_1_2_11_35_1","first-page":"223","article-title":"The in vivo effect of dry hydro\u2010alcoholic extract of Echinacea purpurea on angiogenic activity of human blood mononuclear cells","volume":"35","author":"Skopinska\u2010Rozewska E.","year":"2010","journal-title":"Central\u2010European Journal of Immunology"},{"issue":"2","key":"e_1_2_11_36_1","first-page":"437","article-title":"Effect of Thymus vulgaris and Satureja khuzestanica ethanolic extracts on broiler chickens\u2019 performance and immune response","volume":"5","author":"Souri H.","year":"2015","journal-title":"Iranian Journal of Applied Animal Science"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013\u201003697"},{"issue":"40","key":"e_1_2_11_38_1","first-page":"6819","article-title":"Performance, immunity, serum biochemical and hematological parameters in broiler chicks fed dietary thyme as alternative for an antibiotic growth promoter","volume":"9","author":"Toghyani M.","year":"2010","journal-title":"African Journal of Biotechnology"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2011.09.026"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.08.032"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045380\u2010z"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2012\u201002764"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013\u201003147"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/82.6.1030"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pew239"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pey119"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.4081\/ijas.2014.3238"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:20:20Z","timestamp":1781875220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/vms3.70028"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70028","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70028"}}