{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:27Z","timestamp":1772118807143,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Post\u2010operative new\u2010onset atrial fibrillation (POAF) is a possible complication following cardiac surgery. Digoxin is a drug with positive inotropic and negative chronotropic effects and is listed among antiarrhythmic drugs that can be prescribed in dogs with atrial fibrillation. This report aims at describing the use of digoxin in two dogs with persistent POAF after mitral valve repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Case 1 was a Toy Poodle, neutered male, 12 years old, weighing 5.0\u00a0kg. The patient was diagnosed with the American College of Veterinary Internal Medicine (ACVIM) Stage D myxomatous mitral valve disease without arrhythmia. The day of the surgery was defined as Day 1. Persistent POAF was diagnosed on Day 30 (1\u2010min mean heart rate of 206\u00a0bpm by in\u2010clinic electrocardiogram), and treatment with digoxin was started at a dose of 0.0040\u00a0mg\/kg, p12h. The resolution of atrial fibrillation (AF) was confirmed at the follow\u2010up visit on Day 58 (1\u2010min mean heart rate of 162\u00a0bpm by in\u2010clinic electrocardiogram). Case 2 was a mixed\u2010breed dog, neutered male, 12 years old, weighing 7.6\u00a0kg. The patient was diagnosed with ACVIM Stage B2 myxomatous mitral valve disease without arrhythmia. After surgery, the patient had a normal sinus rhythm, but a paroxysmal ectopic atrial rhythm was observed on Day 32. Persistent POAF was diagnosed on Day 130 (1\u2010min mean heart rate of 216\u00a0bpm by in\u2010clinic electrocardiogram), and treatment with digoxin was started at a dose of 0.0037\u00a0mg\/kg, p12h. The resolution of AF was confirmed on Day 151 (1\u2010min mean heart rate of 107\u00a0bpm by in\u2010clinic electrocardiogram).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>In this report, the authors suspected that digoxin therapy could have contributed, among other factors, to cardioversion. However, specifically designed studies are needed to confirm this preliminary hypothesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70029","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T09:48:03Z","timestamp":1736934483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of two dogs with post\u2010operative new\u2010onset persistent atrial fibrillation following mitral valve repair"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-7769","authenticated-orcid":false,"given":"Kentaro","family":"Kurogochi","sequence":"first","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"},{"name":"Department of Clinical Sciences College of Veterinary Medicine, North Carolina State University  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Masaki","sequence":"additional","affiliation":[{"name":"You Animal Medical Center  Gotemba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori Goto","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Veterinary Specialists Emergency Center  Kawaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Uechi","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci11010047"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70055-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16297"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.0015.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001133"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0166-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12363"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0301.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000132482.95686.87"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.5.739"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx039"},{"key":"e_1_2_10_13_1","first-page":"814","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Hoffman B. 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