{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:18:54Z","timestamp":1782209934647,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac troponin I, a particular biomarker, is released into the bloodstream in response to myocardial injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate perioperative changes in high\u2010sensitivity cardiac troponin I (hs\u2010cTnI) concentration during ovariohysterectomy in cats undergoing three different anaesthesia protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\u00a0Twenty\u2010one female mixed\u2010breed cats owned by clients aged (2.2 \u00b1 0.7 years) and weight (3.2 \u00b1 0.5 kg) were included in our study. The cats were divided into three groups: propofol\u2013isoflurane (PI) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), xylazine\u2013ketamine (XK) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and xylazine\u2013isoflurane (XI) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). After pre\u2010anaesthetic propofol (6\u00a0mg\/kg IV) was administered to cats in Group PI, a mask was placed, and anaesthesia was maintained with 3.0% isoflurane in oxygen. Cats in Group XK underwent general anesthetization with xylazine hydrochloride (2\u00a0mg\/kg\u00a0IM) and, 10\u00a0min later, ketamine hydrochloride (10\u00a0mg\/kg\u00a0IM). Cats in Group XI were administered xylazine hydrochloride (2\u00a0mg\/kg\u00a0IM), and then anaesthesia (3.0% isoflurane and oxygen) was continued with a mask. Blood samples were collected from all cats; preoperatively and postoperatively at 0 and 12\u00a0h (Pre\u2010, Post\u20100\u00a0h and Post\u201012\u00a0h, respectively). Serum hs\u2010cTnI concentrations were measured with the Advia Centaur TnI\u2010Ultra.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all 21 cats, hs\u2010cTnI concentration increased at Post\u20100\u00a0h and 12\u00a0h measurement points compared to Pre\u2010. In the XK group, hs\u2010cTnI concentrations exhibited a significant increase at the Post\u20100\u00a0h (51.30\u00a0ng\/L) and Post\u201012\u00a0h (157.70\u00a0ng\/L) time points compared to Pre\u2010 (6.70\u00a0ng\/L) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The XK group increased the concentration of hs\u2010cTnI more than other protocols. In the PI group, the increase in hs\u2010cTnI concentrations at Post\u20100 and 12\u00a0h increased less than the other two groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The PI group was found to induce less myocardial damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.70050","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T17:34:18Z","timestamp":1727285658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perioperative Change of High\u2010Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-4641","authenticated-orcid":false,"given":"Tarik","family":"Safak","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine Kastamonu University  Kastamonu T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-9471","authenticated-orcid":false,"given":"Oznur","family":"Y\u0131lmaz\u2010Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine Siirt University  Siirt T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Karakaya\u2010Bilen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Ceyhan Veterinary Medicine Cukurova University  Adana T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/LR7FC0LUGLHT8X6J"},{"issue":"2","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0022-3565(25)10402-3","article-title":"Hemodynamic and Sedative Effects of Dexmedetomidine in Dog","volume":"263","author":"Bloor B. 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