{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:07Z","timestamp":1772118907244,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The translocation of gingival commensals resulting in measurable systemic inflammation has been described in humans and non\u2010equine veterinary species with dental disorders, particularly periodontal disease. Routine odontoplasty does not result in increased serum amyloid A (SAA) concentration in horses, but a measurable increase in SAA concentration in horses undergoing dental extractions could suggest that local inflammation resulting from more severe dental disease has potential for wider, systemic consequences that warrants further study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether SAA increases in horses undergoing simple, oral extraction of non\u2010fractured cheek teeth with and without periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      SAA was measured using a stall\u2010side test in horses undergoing simple oral extraction of cheek teeth with intact clinical crowns at baseline (\n                      <jats:italic>T<\/jats:italic>\n                      = 0), 24 h (\n                      <jats:italic>T<\/jats:italic>\n                      = 24) and 48 h (\n                      <jats:italic>T<\/jats:italic>\n                      = 48) post\u2010extraction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight horses and 4 ponies aged between 4 and 23 years underwent cheek tooth extraction. A statistically significant difference in SAA concentration was noted between groups with and without periodontal disease at both 24 h (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and 48 h (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.043). At 24\u00a0h, the median SAA concentration was 135\u00a0mg\/L (range: 0\u2013260\u00a0mg\/L; IQR: 77.5\u2013174\u00a0mg\/L) in horses with periodontal disease and 27.5\u00a0mg\/L (range: 0\u201347\u00a0mg\/L; IQR: 4.8\u201343.5\u00a0mg\/L) in horses without periodontal disease. At 48\u00a0h, median SAA concentration was 264\u00a0mg\/L (range: 236\u2013440\u00a0mg\/L; IQR: 245.5\u2013300.5\u00a0mg\/L) in horses with periodontal disease and 0\u00a0mg\/L (range = 0\u201341\u00a0mg\/L; IQR: 0\u201321.8\u00a0mg\/L) in horses without periodontal disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Limitations<\/jats:title>\n                    <jats:p>Small sample group. Horses undergoing extraction of fractured cheek teeth were not included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Extraction of non\u2010fractured cheek teeth does not result in a remarkable increase in SAA, except in horses with periodontal disease. These results suggest that periodontal disease in horses is associated with a local inflammatory response, which in turn drives the development of systemic inflammation, resulting in detectable increases in inflammatory markers when diseased periodontal tissues are disturbed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70104","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T09:23:25Z","timestamp":1730971405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Simple Oral Dental Extraction on Systemic Serum Amyloid A Concentrations in Horses"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6307-2593","authenticated-orcid":false,"given":"Amelia E.","family":"Sidwell","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham UK"},{"name":"Pool House Equine Hospital IVC Evidensia  Lichfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Duz","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeel","family":"Khan","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Bodn\u00e0r","sequence":"additional","affiliation":[{"name":"Pool House Equine Hospital IVC Evidensia  Lichfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam Luis","family":"Hole","sequence":"additional","affiliation":[{"name":"Pool House Equine Hospital IVC Evidensia  Lichfield 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