{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:12:36Z","timestamp":1792465956919,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastric ulcer (GU) is the most common health concern that occurs due to an imbalance between gastric protective mucosal and aggressive factors. Ethanol\u2010induced GU in animal models resembles the pathophysiology of human ulcers. Natural products with fewer side effects are highly requested to attenuate their GU effects. The present study was conducted to investigate the potential protective effects of donkey milk against ethanol\u2010induced GU in rats. The male Wistar were divided into four groups, including normal control (distilled water), donkey milk (1\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    \/animal) and ranitidine (200\u00a0mg\/kg). Donkey milk and ranitidine were given to rats orally daily for 10 consecutive days before induction of ulcer by ethanol. After 24\u00a0h of fasting, GU was induced by oral administration of ethanol. After an hour, the rats were sacrificed, and gastric samples were taken for pathologic analysis, malondialdehyde (MDA) and glutathione (GSH) assessments. The results showed that the severity of ethanol\u2010induced gastric damage was significantly reduced by donkey's milk pretreatment and then ranitidine. Reduction of ulcer score and MDA level, and also increasing GSH in the gastric tissue in comparison with other groups supports our results. This study described the gastroprotective and antioxidative effects of donkey milk that were determined with ulcer inhibition percentage.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70156","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:43:38Z","timestamp":1734000218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Protective Effects of Donkey Milk on Ethanol\u2010Induced Gastric Ulcer in Rat"],"prefix":"10.1002","volume":"11","author":[{"given":"Masoud","family":"Sami","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology School of Nutrition and Food Science Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3746-9593","authenticated-orcid":false,"given":"Shahrzad","family":"Azizi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kheirandish","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Ebrahimnejad","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene and Public Health Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine Shahid Bahonar University of Kerman Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00810.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.11.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790883651"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776117827"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2016.1175014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13594-015-0246-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2012.08.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.11.017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2008.01.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14030979"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-36"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobaz.2015.03.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2022.104006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2006-600"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051537"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10101985"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790883688"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.030"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112221"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104603"},{"key":"e_1_2_10_23_1","first-page":"153","article-title":"Ass's Milk in Allergy to Cow's Milk Protein: A Review","volume":"29","author":"Mansueto P.","year":"2013","journal-title":"Acta Medica Mediterranea"},{"issue":"2","key":"e_1_2_10_24_1","first-page":"136","article-title":"Therapeutic Applications of Whey Protein","volume":"9","author":"Marshall K.","year":"2004","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11051382"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.1104"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2267-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml400158k"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-013-9594-y"},{"issue":"7","key":"e_1_2_10_30_1","first-page":"1005","article-title":"Peptic Ulcer Disease","volume":"76","author":"Ramakrishnan K.","year":"2007","journal-title":"American Family Physicians"},{"key":"e_1_2_10_31_1","first-page":"244","article-title":"Rang & Dale's Pharmacology","author":"Ritter J. M.","year":"2014","journal-title":"Elsevier Health Sciences"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(83)90424-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2004.7.309"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.01.002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2012.03.007"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70705-8"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2016v8i9.12846"},{"issue":"2","key":"e_1_2_10_38_1","first-page":"737","article-title":"Epidermal Growth Factor (EGF) in Mare and Ass Milk: A Preliminary Investigation","volume":"8","author":"Scafizzari M.","year":"2009","journal-title":"Italian Journal of Animal Sciences"},{"issue":"4","key":"e_1_2_10_39_1","first-page":"696","article-title":"Potentiation of the Gastroprotective Effect of Ranitidine by Verapamil in Ethanol\u2010induced Ulcer in Rats","volume":"4","author":"Sharif Z.","year":"2010","journal-title":"International Journal of Pharmaceutical and Biological Archives"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207783018590"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.59645"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-35-19"},{"issue":"5","key":"e_1_2_10_43_1","first-page":"600","article-title":"Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider","volume":"50","author":"Turner P. V.","year":"2011","journal-title":"Journal of American Association for Laboratory Animal Science"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.07.027"},{"issue":"109","key":"e_1_2_10_46_1","first-page":"2161","article-title":"A Proteomic Study on Donkey Milk","volume":"1","author":"Vincenzetti S.","year":"2012","journal-title":"Biochemical and Analytical Biochemistry"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.2202\/1556-3758.2032"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.489"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2017-13872"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-016-1304-z"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T06:41:43Z","timestamp":1747896103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/vms3.70156"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70156","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.70156\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70156\/v2\/response1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2023-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70156"}}