{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:42:06Z","timestamp":1780393326801,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160833"],"award-info":[{"award-number":["32160833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of this experiment was to understand the impact of fatty acid binding protein 4 (FABP4)\u2010mediated inflammation on sheep endometrial epithelial cells (sEECs). To model\u00a0the hormonal environment of sheep during pregnancy, estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ), progesterone (P\n                    <jats:sub>4<\/jats:sub>\n                    ) and interferon\u2010tau (IFN\u2010\u03c4) were used. The sEECs were then stimulated with different concentrations of lipopolysaccharide (LPS) to determine suitable concentrations for inducing inflammation, while FABP4 expression was inhibited using a FABP4\u2010specific inhibitor. The expression of genes related to inflammation, cell apoptosis, cell proliferation, endometrial tolerance, and embryo development were detected by real\u2010time quantitative PCR and Western blot. The cell proliferation ability was detected by CCK\u20108, and the cell migration ability was tested by scratch assay. The results showed that LPS\u2010induced inflammation inhibited the expression levels of proliferation genes, migration ability genes and endometrial tolerance\u2013related genes and enhanced the expression levels of apoptosis genes and gestational elongation\u2013related genes and proteins in the sEECs. The use of FABP4 inhibitors reduced LPS\u2010induced inflammation and alleviated the inhibitive effect of LPS on cellular function. The experiments showed that inhibiting the expression of the FABP4 gene reduced LPS\u2010induced inflammation and alleviated the impact of LPS on the viability of sEECs.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70193","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:32:52Z","timestamp":1741728772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FABP4 Mediates Inflammation to Regulate Endometrial Epithelial Cell Function During Early Gestation in Sheep"],"prefix":"10.1002","volume":"11","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijiao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengbin","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayu","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4486-3994","authenticated-orcid":false,"given":"Guangdong","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.10.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02796-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.03.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13526"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02317"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/pulp.1996.0017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07780-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318256a0fe"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.122"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12495"},{"issue":"11","key":"e_1_2_9_13_1","first-page":"2865","article-title":"Estrogen, Progesterone\u2013Biosynthesis, Receptor and Action","volume":"55","author":"Kamada M.","year":"1997","journal-title":"Nihon Rinsho"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"205","article-title":"Embryo Implantation and Pregnancy: Immunologic Intricacies and Strategies for Its Success","volume":"75","author":"Kumar G. 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