{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:15:46Z","timestamp":1772118946320,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of the study was to evaluate the effect of\n                    <jats:italic>Epilobium parviflorum<\/jats:italic>\n                    (EP) as a treatment for benign prostatic hyperplasia (BPH) in dogs based on two clinical case reports. Two dogs with BPH were treated for 2 months with EP extract. For both cases, follow\u2010up was performed with B\u2010mode ultrasound on Days 7, 15, 30 and 60 after starting treatment, and measurements of the length, width and height of the prostate were taken to calculate its volume (cm\n                    <jats:sup>3<\/jats:sup>\n                    ). A complete blood count, liver and kidney biochemistry, urinalysis and serum testosterone concentration (ng\/dL) were completed at the same time points. EP was well tolerated with no side effects observed during the 60\u2010day oral administration period. In both cases, prostate volume decreased by 40% (Case 1: 81\u201350\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    ; Case 2: 79\u201344\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    ) by Day 60. Serum testosterone concentration decreased by 30% for Case 1 (749\u2013512\u00a0ng\/dL) and 20% for Case 2 (220\u2013188\u00a0ng\/dL). This case report describes an alternative therapeutic method effective for treating canine BPH without apparent adverse reactions or complications.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70205","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:34:13Z","timestamp":1741732453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of\n                    <i>Epilobium parviflorum<\/i>\n                    in the Treatment of Benign Prostatic Hyperplasia in Canines"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-2439","authenticated-orcid":false,"given":"Guillermo","family":"Cazzuli","sequence":"first","affiliation":[{"name":"Unidad de Imagenolog\u00eda y Laboratorios de An\u00e1lisis Cl\u00ednicos y Endocrinolog\u00eda y Metabolismo Animal, Departamento de Cl\u00ednicas y Hospital Veterinario, Facultad de Veterinaria, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-5743","authenticated-orcid":false,"given":"Juan Pablo","family":"Dami\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Bioqu\u00edmica, Departamento de Biociencias Veterinarias, Facultad de Veterinaria, Universidad de la Rep\u00fablica  Montevideo Uruguay"},{"name":"N\u00facleo de Bienestar Animal, Facultad de Veterinaria, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Minini","sequence":"additional","affiliation":[{"name":"Laboratorio de Carbohidratos y Glicoconjugados, Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica (UdelaR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratorio de Carbohidratos y Glicoconjugados, Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica (UdelaR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Unidad de Farmacolog\u00eda y Terap\u00e9utica, Departamento de Cl\u00ednicas y Hospital Veterinario, Facultad de Veterinaria, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Pessina","sequence":"additional","affiliation":[{"name":"Unidad de Imagenolog\u00eda y Laboratorios de An\u00e1lisis Cl\u00ednicos y Endocrinolog\u00eda y Metabolismo Animal, Departamento de Cl\u00ednicas y Hospital Veterinario, Facultad de Veterinaria, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.163.6.179"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2203"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234714"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.03.031"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5455\/OVJ.2023.v13.i10.10"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2013.01.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.11.045"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111414"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.05.009"},{"issue":"7","key":"e_1_2_9_12_1","first-page":"56","article-title":"Adverse Effects and Safety of 5\u2010Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review","volume":"9","author":"Hirshburg J. 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