{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:38:30Z","timestamp":1791268710582,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pregnancy toxemia (PT) is a common metabolic disorder that occurs in the last trimester of pregnancy. This study aimed to detect the effects of subclinical PT (SPT) on serum biochemical parameters of ewes and postnatal growth and development of lambs in Romanov sheep. A total of\u00a040 ewes and 69 lambs\u00a0were included in the study. Blood samples of ewes were collected at the time of parturition to evaluate serum beta\u2010hydroxybutyric acid (\u03b2HBA), serum nonesterified fatty acid (NEFA), cholesterol, and triglyceride. Live weight and body measurements of lambs were recorded at birth (0th day), 30th day, and 60th (weaning) day.\u00a0In the diagnosis of SPT\u00a0serum\u00a0\u03b2HBA\u00a0concentrations were\u00a0taken\u00a0into account. A cut\u2010off value of 0.8\u00a0mmol\/L for \u03b2HBA was a critical\u00a0concentration\u00a0and\u00a0ewes with 0.8\u20131.6\u00a0mmol\/L \u03b2HBA\u00a0were evaluated\u00a0as SPT. There were no ewes with \u0392HBA value higher than 1.6\u00a0mmol\/L (clinical PT) in the study. There was no significant difference in serum \u03b2HBA, NEFA and cholesterol concentrations between ewes regarding birth type (single, twin, and triplet).\u00a0However, triglyceride concentrations were higher (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001)\u00a0in\u00a0ewes giving birth to triplets compared to\u00a0ewes giving birth to single lamb. Serum \u03b2HBA and triglyceride concentrations were higher (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01)\u00a0in ewes with SPT (\n                    <jats:italic>n<\/jats:italic>\n                    = 14)\u00a0compared to healthy\u00a0ewes (\n                    <jats:italic>n<\/jats:italic>\n                    = 26). There was no significant difference\u00a0between ewes with SPT and healthy ewes in serum NEFA and cholesterol. Repeated measures ANOVA results indicated that SPT negatively affected 0th, 30th, and 60th body weights of twin (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01) and triplet born lambs (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The effect of time on body weights was also found to be significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Similarly, most\u00a0of the\u00a0body measurements of twin and triplet born lambs were lower (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) in the SPT group compared to healthy group. Overall results indicate that SPT may negatively affect postnatal growth and development in Romanov lambs. Because a decline in growth performance has many\u00a0negative\u00a0outcomes affecting production traits in sheep, these findings may be valuable for the veterinary field.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70259","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T08:39:53Z","timestamp":1745311193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Subclinical Pregnancy Toxemia Affects Blood Parameters of Ewes and Impairs Postnatal Growth and Development of Lambs"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-0939","authenticated-orcid":false,"given":"Ali Osman","family":"Turgut","sequence":"first","affiliation":[{"name":"Department of Animal Science Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcrsel","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-2859","authenticated-orcid":false,"given":"Mehmet","family":"Irmak","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disease Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cahit","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disease Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-6959","authenticated-orcid":false,"given":"Davut","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erman","family":"G\u00fclenda\u011f","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Furkan","family":"\u00d6nen","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmi","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disease Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"\u00dcnver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Halil","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disease Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.37496\/rbz5220220114"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.37496\/rbz5020200213"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"169","article-title":"Effect of Inbreeding on Different Performance Traits of Hissardale Sheep in Pakistan","volume":"20","author":"Akhtar P.","year":"2000","journal-title":"Pakistan Veterinary Journal"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"5","article-title":"Environmental Factors Affecting Birth Weight in Lohi Sheep","volume":"24","author":"Babar M. E.","year":"2004","journal-title":"Pakistan Veterinary Journal"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2010.10.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2014.971083"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13040666"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2009-2311"},{"issue":"4","key":"e_1_2_11_10_1","first-page":"469","article-title":"The Estimation of Live Weight From Body Measurements in Different Meat\u2010type Lambs","volume":"27","author":"Esen V. K.","year":"2021","journal-title":"Journal of Agricultural Science"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"1","article-title":"Pregnancy Toxemia in Ovis aries, and Role of Metabolic Disorder Causing It","volume":"9","author":"Gaadee H. I. M.","year":"2021","journal-title":"Research Journal for Veterinary Practitioners"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skz388"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2005.10.010"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2015-9933"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-022-03339-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00069"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14542"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2016.10.012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-3905"},{"key":"e_1_2_11_20_1","volume-title":"Nutrient Requirements of Small Ruminants: Sheep, Goats, Cervids, and New World Camelids","author":"National Research Council","year":"2007"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2018.03.009"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-5-43"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30107-9"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600024874"},{"issue":"2","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.17094\/ataunivbd.813491","article-title":"Romanov Koyun Irk\u0131nda D\u00f6lverimi \u00d6zellikleri, Ya\u015fama G\u00fcc\u00fc, B\u00fcy\u00fcme Performans\u0131 Ve Baz\u0131 V\u00fccut \u00d6l\u00e7\u00fcleri","volume":"16","author":"\u015een M.","year":"2021","journal-title":"Atat\u00fcrk \u00dcniversitesi Veteriner Bilimleri Dergisi"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.18\u20100777"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.254.7.859"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13738"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250\u2010022\u201003068\u2010z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2013001000002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11092733"},{"issue":"2","key":"e_1_2_11_32_1","first-page":"271","article-title":"Milk Composition Traits of Hamdani Crossbreed Sheep Raised Under Extensive Management","volume":"7","author":"Turgut A. O.","year":"2023","journal-title":"The Journal of Agricultural Science"},{"issue":"1","key":"e_1_2_11_33_1","first-page":"205","article-title":"SerumAnti\u2010M\u00fcllerian Hormone Levels During Estrus and Diestrus Phases of the Estrous Cycle and Its Possible Effect on Fertility in Cross\u2010bred Hamdani Sheep","volume":"44","author":"Turgut A. O.","year":"2024","journal-title":"Pakistan Veterinary Journal"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14589"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14482"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-0929.2005.00265.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.13197"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731118002136"},{"issue":"1","key":"e_1_2_11_39_1","first-page":"1","article-title":"Ankara \u015fartlarinda Akkaraman, Ivesi ve Kivircik irklarinda d\u00f6l verimi, b\u00fcy\u00fcme ve ya\u015fama g\u00fcc\u00fc","volume":"52","author":"Yakan A.","year":"2012","journal-title":"Lalahan Hayvanc\u0131l\u0131k Ara\u015ft\u0131rma Enstit\u00fcs\u00fc Dergisi"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/vms3.70259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:20:27Z","timestamp":1774268427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/vms3.70259"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70259","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"2024-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70259"}}