{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:47:01Z","timestamp":1788234421624,"version":"build-2803163510"},"reference-count":89,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The microbiota includes prokaryotes (archaea and bacteria) and eukaryotes. Archaea are single\u2010celled prokaryotes and essential part of gut microbiome. Researches on archaea in ruminants and humans are more than mono\u2010gastric. The low abundance of archaea in the gut depends on the method used (metagenomics or meta\u2010transcriptomic) and age of people or poultry. The lack of complete recognition of archaea is due to their small number and method of identifying them (16S rRNA gene primers). The uses of archaea include analytical kit, reduce oil pollution, archaeosomes or drugs production, vaccines agents, lipid carriers in the pharmaceutical industry and molybdenum extraction in the nuclear industry. The nutritional functions of methanogenic archaea including feed utilization (ruminants) and efficiency, hydrogen reducing (human), fat deposition and enhancement of energy harvesting in mice, CAZymes genes, cecal fermentation, syntrophic potential, carotenoid source and improved transit time and appetite and SCFAs production. Archaea acting as antibiotics (produce archaeocins, sulfolobicins and halocin KPS1) and as probiotics (archaeobiotics) can reduce TMAU (trimethylaminuria) disease, cardiovascular diseases (CVDs), and atherosclerosis, brain abscess, cancer, colorectal cancer, inflammatory bowel disease (IBD), constipation, obesity, food allergies, asthma and anti\u2010inflammation which can be prevented by using archaea, and other functions include energy homeostasis, heat shock protein (HSP) production and reducing aging.<\/jats:p>","DOI":"10.1002\/vms3.70263","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T06:39:14Z","timestamp":1740983954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Spotlight on Archaea in Humans, Livestock and Poultry: A Review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-3664","authenticated-orcid":false,"given":"Ahmad","family":"Salahi","sequence":"first","affiliation":[{"name":"Department of Animal Science Faculty of Agriculture University of Zanjan  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-3831","authenticated-orcid":false,"given":"Wafaa A.","family":"Abd El\u2010Ghany","sequence":"additional","affiliation":[{"name":"Department of Poultry Diseases Faculty of Veterinary Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520000380"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2023.104080"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007125"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.115"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13020317"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"82","article-title":"Methanobrevibacter smithii Isolation From human Stool Using Specific rpoB Gene","volume":"26","author":"Baradaran Ghavami S.","year":"2016","journal-title":"Medical Sciences"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.02.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02268\u201012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.06.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.04.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023326"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annweh\/wxz058"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010020\u20100407\u2010y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26749"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(06)72137\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/282035"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010021\u201001020\u20109"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14020196"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.09.17.302828"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11072139"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106941.2007.00394.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13178"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2018.00216"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100463.2012.02899.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.03.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0751528"},{"issue":"2","key":"e_1_2_9_28_1","first-page":"560","article-title":"Archaeabacterias hiperterm\u00f3filas: Vida en Ebullici\u00f3n","volume":"1","author":"Fern\u00e1ndez P. G.","year":"2007","journal-title":"Revista Complutense De Ciencias Veterinarias"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002489900162"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/d11090156"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066019"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.01.012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.783295"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm\u20102012\u20100305"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3923\/rjbsci.2011.257.262"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5187\/jast.2020.62.1.31"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010020\u201000894\u2010x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462\u20102920.12376"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00824\u201017"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010021\u201001130\u2010w"},{"key":"e_1_2_9_41_1","volume-title":"Archaea in Bioaerosols in Dairy Farms, Poultry Houses and Wastewater Treatment Plants and Their Role in Lung Inflammation Chemical and Biological Hazards Prevention","author":"Lecours P. B.","year":"2014"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835eb916"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165754"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00061\u201017"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010019\u20100618\u20105"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/147671"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8030228"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010019\u20101459\u2010x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758\u20102229.2009.00116.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0723\u20102020(86)80084\u20104"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/applmicrobiol4010012"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2022.102146"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.02.09.579604"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.07.004"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010micro\u2010091213\u2010112901"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00726\u201009"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934\u2010015\u20100302\u20109"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.96.6.2178-2179.1968"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015574"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.973508"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2020.107668"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731113000864"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2019.116823"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.931"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.904698"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038\u2010017\u20109668\u20107"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113935"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284\u2010005\u20100036\u20108"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01931\u201006"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472\u2010765X.2007.02243.x"},{"issue":"1","key":"e_1_2_9_73_1","article-title":"Supernatant Metabolites From Halophilic Archaea to Reduce Tumorigenesis in Prostate Cancer In\u2010Vitro and In\u2010Vivo","volume":"18","author":"Safarpour A.","year":"2019","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13972"},{"issue":"2","key":"e_1_2_9_75_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.18016\/ksujns.16522","article-title":"The Effects of Chicken Box, Chick Paper Type and Flock Age on Sound Level and Leg Abnormalities in One\u2010Day Old Chicks in the Hatchery","volume":"17","author":"Salahi A.","year":"2014","journal-title":"KS\u00dc Do\u011fa Bilimleri Dergisi"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1517\u201083822013005000023"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.060218710SamuelBS"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704189104"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u20108\u201079"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2002\/436561"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envadv.2022.100304"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.1997.tb12618.x"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00871644"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010micro\u2010040921\u2010050212"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102672.2006.02989.x"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010021\u201001040\u2010x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1182288"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010021\u201000980\u20102"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010013\u20100429\u20108"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02247"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:13:26Z","timestamp":1747196006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/vms3.70263"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70263","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/VMS3.70263\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v5\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/VMS3.70263\/v4\/review1","asserted-by":"object"}]},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70263"}}