{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:17:58Z","timestamp":1790727478073,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202001BC070001 202102AA100053"],"award-info":[{"award-number":["202001BC070001 202102AA100053"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Squamous cell carcinoma (SCC) has a high incidence in non\u2010human primates (NHPs), which affects animal health and causes huge losses to the experimental monkey breeding industry. In this case, gastroscope showed a smooth\u2010surfaced elevated lesion located approximately 18\u00a0cm from the incisor teeth of the diseased rhesus monkey. Computed tomography (CT) showed a space\u2010occupying lesion in the oesophagus. Haematoxylin &amp; eosin (HE) staining revealed an invasive tumour of polygonal nests in the submucosa and muscularis, while keratosis and nuclear atypia were also observed. Immunohistochemistry (IHC) studies revealed tumour cells positive for p63, CK5\/6, p40, CK20, CK7 and CK19. Based on imaging and pathology findings, the rhesus monkey was diagnosed as oesophageal squamous cell carcinoma (ESCC) and was treated surgically. Unfortunately, the rhesus monkey was euthanized eventually according to its poor health condition. This provides an important reference for the diagnosis and treatment of ESCC in rhesus monkeys, and also provides an important spontaneous animal model for future research on ESCC.<\/jats:p>","DOI":"10.1002\/vms3.70266","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:17:51Z","timestamp":1739531871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging and Pathological Comprehensive Analysis of Oesophageal Squamous Cell Carcinoma in a Rhesus Monkey (<i>Macaca mulatta<\/i>)"],"prefix":"10.1002","volume":"11","author":[{"given":"Heling","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixian","family":"Chen","sequence":"additional","affiliation":[{"name":"Kunming Biomed International Ltd.  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Kunming Biomed International Ltd.  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6763-3168","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"The Merck Veterinary Manual","author":"Aiello S. 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