{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:17:23Z","timestamp":1753870643964,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1C1C1007282"],"award-info":[{"award-number":["NRF\u20102020R1C1C1007282"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Red blood cell (RBC) indices provide information on the size and haemoglobin content of erythrocytes. The RBC distribution width (RDW) is an index of size variability of the circulating RBC population. The correlation between various diseases and RDW in dogs has been demonstrated. Some studies have evaluated RDW in dogs with myxomatous mitral valve disease (MMVD), and conflicting results have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the association between RBC indices, complete blood cell counts (CBC), and serum biochemical and echocardiographic variables in small\u2010breed dogs with MMVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RBC indices, CBC, and serum biochemical and echocardiographic variables were retrospectively investigated in 102 client\u2010owned dogs with MMVD at various disease stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RBC indices were not statistically significant among groups (control group, compensated group, decompensated group). RDW had a significant positive correlation with haematocrit (Hct) (correlation coefficient, 0.452) and a negative correlation with MCH (correlation coefficient, \u22120.498) and MCV (correlation coefficient, \u22120.357). The end\u2010diastolic volume index, fractional shortening (%), and left atrial\u2010anteroposterior diameter normalised for body weight were echocardiographic variables that affected MMVD severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed no correlation between RBC indices and MMVD. However, conflicting results have been reported in several other studies; thus, further studies should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.70284","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:27:54Z","timestamp":1741746474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Red Blood Cell Indices and Myxomatous Mitral Valve Disease in Small\u2010Breed Dogs: A Retrospective Study"],"prefix":"10.1002","volume":"11","author":[{"given":"Eui\u2010Joo","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine and Institute of Veterinary Science College of Veterinary Medicine Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine and Institute of Veterinary Science College of Veterinary Medicine Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-9482","authenticated-orcid":false,"given":"Ju\u2010Hyun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Veterinary Emergency and Critical Care Medicine College of Veterinary Medicine Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sooyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic Imaging College of Veterinary Medicine Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-9834","authenticated-orcid":false,"given":"Jin\u2010Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine and Institute of Veterinary Science College of Veterinary Medicine Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3300-6084","authenticated-orcid":false,"given":"Jin\u2010Ok","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine and Institute of Veterinary Science College of Veterinary Medicine Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000134279.79571.73"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02551.x"},{"volume-title":"Clinical Echocardiography of the Dog and Cat","year":"2015","author":"De Madron E.","key":"e_1_2_11_4_1"},{"volume-title":"Textbook of Veterinary Internal Medicine\u2010Inkling E\u2010Book","year":"2016","author":"Ettinger S. J.","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.067"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00111.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.6.858"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11030778"},{"volume-title":"Veterinary Hematology","year":"2012","author":"Harvey S.","key":"e_1_2_11_10_1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.11.043"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.08.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2013.09.015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15488"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2478\/jvetres-2020-0043"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.19-0240"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14524"},{"issue":"9","key":"e_1_2_11_19_1","first-page":"964","article-title":"Evaluation of Red Blood Cell Distribution Width in Dogs With Various Illnesses","volume":"60","author":"Martinez C.","year":"2019","journal-title":"The Canadian Veterinary Journal"},{"volume-title":"Small Animal Diagnostic Ultrasound","year":"2002","author":"Nyland T. G.","key":"e_1_2_11_20_1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.01.011"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.01.002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13146"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000664"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.051"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.992064"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.24425\/122625"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.583666"},{"volume-title":"Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat\u2010E\u2010Book","year":"2019","author":"Valenciano A. C.","key":"e_1_2_11_29_1"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:15:20Z","timestamp":1747210520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/vms3.70284"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70284","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"type":"print","value":"2053-1095"},{"type":"electronic","value":"2053-1095"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"2023-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70284"}}