{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:38:57Z","timestamp":1768451937211,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigated the impact of drinking hydrogen\u2010rich water (HRW) on growth performance, organ weights, thiol\/disulphide homeostasis, oxidative status and some hormonal, histopathological and immunohistochemical changes in rats fed in a restricted housing environment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The eight groups (each group [male\/female] eight rats) comprised two control, two hydrogen, two stress and two stress\u00a0+\u00a0hydrogen. All animals were given feed and water ad libitum for 3 months. Control and HRW group rats were calculated according to weight and housed according to the Guide's housing condition. The stress group and stress\u00a0+\u00a0HRW group were housed in half the area of the Guide's housing condition according to their weight. The animal's weekly body weights were measured throughout the study. The animals were sacrificed in accordance with ethical rules. Then, biochemical analyses were performed on thyroid\u2010stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), cortisol, parathyroid hormone (PTH) and calcium (Ca<jats:sup>2+<\/jats:sup>), total thiol (TT), native thiol (NT), disulphide, disulphide\/TT\u00a0\u00d7\u00a0100, disulphide\/NT\u00a0\u00d7\u00a0100 and NT\/TT\u00a0\u00d7\u00a0100, malondialdehyde (MDA) and glutathione (GSH). Haematoxylin staining for histopathological and SOD\u20102 immunoreactivity was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that live weight gain was higher in the HRW groups than in the stress group. Oxidant status in biochemical analyses decreased in the stress\u00a0+\u00a0HRW group compared to the stress group. TSH decreased in the stress group. FT4, cortisol and Ca<jats:sup>2+<\/jats:sup> increased in the stress group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The stress\u2010related physiological parameters were reduced in the HRW\u00a0+\u00a0stress group compared to the stress group. HRW could be suggested when the organism is found in stressful conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/vms3.70305","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T08:44:26Z","timestamp":1742373866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Hydrogen\u2010Rich Water on Growth, Redox Homeostasis and Hormonal, Histological and Immune Systems in Rats Exposed to High Cage Density Stress"],"prefix":"10.1002","volume":"11","author":[{"given":"Buket","family":"Bo\u011fa Kuru","sequence":"first","affiliation":[{"name":"Department of Animal Breeding and Husbandry Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-8180","authenticated-orcid":false,"given":"Mustafa","family":"Makav","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-251X","authenticated-orcid":false,"given":"Mushap","family":"Kuru","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckran Yediel","family":"Aras","sequence":"additional","affiliation":[{"name":"Department of Midwifery Faculty of Health Sciences Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Karada\u011f Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Histology\u2010Embryology Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menek\u015fe","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Food Engineering Faculty of Engineering I\u011fd\u0131r University  I\u011fd\u0131r T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duried","family":"Alwazeer","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences I\u011fd\u0131r University  I\u011fd\u0131r T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikret","family":"Bekta\u015fo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Husbandry Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fckremin","family":"\u00d6lmez","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Diseases Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgut","family":"K\u0131rm\u0131z\u0131bayrak","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Husbandry Faculty of Veterinary Medicine Kafkas University  Kars T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-6728","authenticated-orcid":false,"given":"Tyler W.","family":"LeBaron","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Outdoor Recreation Southern Utah University  Cedar City Utah USA"},{"name":"Molecular Hydrogen Institute  Enoch Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.9775\/KVFD.2021.25390"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-47375-3_19"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5513868"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5513868"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(84)90066\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PSYNEUEN.2013.02.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.17343\/SDUTFD.566969"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.36472\/msd.v9i8.784"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/16583655.2018.1465275"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1501\/Vetfak_0000001544","article-title":"C Vitamini Uygulanan Ve Uygulanmayan Tavuklarda Acth'nin Glukoz Ve Insolin D\u00fczeylerine Etkisi","volume":"41","author":"Bahri E.","year":"1994","journal-title":"Ankara \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ANTIOX9121281"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4314\/SAJAS.V33I3.3774"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.05.003"},{"key":"e_1_2_11_15_1","first-page":"882","article-title":"Improved Method for the Determination of Blood Glutathione","volume":"61","author":"Beutler E.","year":"1963","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300\u20109629(93)90269\u2010A"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20106480(91)90005\u2010Q"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12237304"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11845\u2010021\u201002743\u20108\/FIGURES\/1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.24880\/MAEUVFD.970374"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBAGEN.2014.10.020"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010020\u20100283\u20101"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLINBIOCHEM.2014.09.026"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.9775\/kvfd.2019.22456"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.35440\/hutfd.649302"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.18016\/ksutarimdoga.vi.681294"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2006.03907.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.10.24313301"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCR.2012.03.009"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040527"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.RVSC.2024.105208"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10517\u2010015\u20102953\u20102\/METRICS"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.9775\/kvfd.2021.25733"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.RBMO.2023.103332"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.010"},{"key":"e_1_2_11_36_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"NRC","year":"2011"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1577"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ADMA.202211595"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.9775\/kvfd.2020.24542"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20005"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.31857\/S0044467724030085"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/80.8.1190"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/PS\/79.3.370"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.11.025"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/EJIHPE10040077"},{"key":"e_1_2_11_46_1","unstructured":"Shahid M. A. M. A.Ashraf andS.Sharma.2023.Physiology Thyroid Hormone.StatPearls."},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032129\u2010y"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000082334.17947.11"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2017.12.010"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.789507"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753\u20103322(03)00043\u2010X"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.25100\/cm.v43i3.842"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.85"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/laban0207\u201028"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010021\u201003065\u20107"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(79)90708\u20107"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSS.2018.03.024"}],"container-title":["Veterinary Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/vms3.70305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:17:46Z","timestamp":1747210666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/vms3.70305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/vms3.70305"],"URL":"https:\/\/doi.org\/10.1002\/vms3.70305","archive":["Portico"],"relation":{},"ISSN":["2053-1095","2053-1095"],"issn-type":[{"value":"2053-1095","type":"print"},{"value":"2053-1095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70305"}}