{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:49:19Z","timestamp":1776980959968,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bisphenol A (BPA) is an endocrine\u2010disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti\u2010inflammatory, and antiapoptotic properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to determine the protective effect of naringin against the damage induced by BPA in the brain and testes of commercial chicken.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010day\u2010old cockerel chickens were purchased and reared for 6 weeks and subsequently divided into six groups: group A (control), group B (100\u00a0ppm BPA\u2010treated), group C (BPA and 100\u00a0mg\/kg naringin\u2010treated), Group D (BPA and 200\u00a0mg\/kg naringin\u2010treated), group E (100\u00a0mg\/kg naringin\u2010treated), and group F (200\u00a0mg\/kg naringin\u2010treated). BPA was administered via drinking water, while naringin was administered via oral gavage. Analyses such as biochemical assays, hormonal assays, histopathology, and immunohistochemistry were done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed a decrease in the level of LH, FSH, and testosterone, an increase in the level of oxidative stress markers (MDA and H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ), and alteration in the levels of enzymatic and non\u2010enzymatic antioxidants (GSH, GST, SOD, GPx) in the brain and testes of the BPA\u2010intoxicated group. Histologically, neuronal necrosis and degeneration were observed in the brain, and degeneration of testicular cells was seen in the testes of BPA\u2010intoxicated chickens. Immunohistochemical evaluation revealed low expression of myelin basic protein in the brain and increased expression of caspase 3 in the testes of the BPA\u2010intoxicated group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Naringin reversed the neurotoxicity and reproductive toxicity of BPA by normalizing the values of the altered parameters. Hence, naringin ameliorated the deleterious effects caused by BPA in both the brain and testes by enhancing the antioxidant defence mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70322","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T06:54:18Z","timestamp":1750661658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Effects of Naringin on Bisphenol A\u2010Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens"],"prefix":"10.1002","volume":"11","author":[{"given":"Leah Oluwaseyanu","family":"Esuola","sequence":"first","affiliation":[{"name":"Pan African University Life and Earth Sciences Institute (including Health and Agriculture)  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-876X","authenticated-orcid":false,"given":"Oluwaseun Olarenwaju","family":"Esan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adamu Shafiu","family":"Maikifi","sequence":"additional","affiliation":[{"name":"Pan African University Life and Earth Sciences Institute (including Health and Agriculture)  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-8621","authenticated-orcid":false,"given":"Temitayo Olabisi","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses Olusola","family":"Adetona","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Basic Medical Sciences University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-4431","authenticated-orcid":false,"given":"Oluwasanmi Olayinka","family":"Aina","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-8610","authenticated-orcid":false,"given":"Ademola Adetokunbo","family":"Oyagabemi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-2861","authenticated-orcid":false,"given":"Temidayo Olutayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6745-1119","authenticated-orcid":false,"given":"Omolade Abodunrin","family":"Oladele","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaristus","family":"Nwulia","sequence":"additional","affiliation":[{"name":"College of Medicine Department of Psychiatry and Behavioral Sciences Howard University, Howard University Hospital  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6072-2473","authenticated-orcid":false,"given":"Momoh Audu","family":"Yakubu","sequence":"additional","affiliation":[{"name":"Department of Environmental &amp; 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