{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:57:06Z","timestamp":1780095426071,"version":"3.54.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp; Sci"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Coenzyme Q10 (CoQ10) is a natural antioxidant and plays a vital role in the energy production of animal cells; however, its physiological and biochemical properties in fish are unclear.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The current experiment was investigated to explore the effects of dietary CoQ10 on growth performance and biochemical and physiological attributes of rainbow trout (\n Oncorhynchus mykiss<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A 56\u2010day feeding trial was conducted with 5 experimental diets supplemented with CoQ10 concentrations at 0, 25, 50, 100 and 200\u00a0mg\u00a0kg\n \u22121<\/jats:sup>\n of diet and fed to 400 rainbow trout (10\u00a0\u00b1\u00a00.1\u00a0g, initial body weight).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Dietary supplementation with CoQ10, especially at the highest dietary level, significantly improved the feed conversion ratio, final body weight and lipid and protein efficiency ratio of fish (\n p<\/jats:italic>\n \u00a0<\u00a00.05). Moreover, the fish carcass protein and lipid content significantly increased with supplementation of 200\u00a0mg CoQ10\u00a0kg\n \u22121<\/jats:sup>\n diet (\n p<\/jats:italic>\n \u00a0<\u00a00.05). The blood serum levels of triglycerides (TGs), cholesterol (CHO) and uric acid significantly reduced, whereas albumin, total protein, high\u2010density lipoprotein and lymphocyte count increased with supplementation of 200\u00a0mg CoQ10\u00a0kg\n \u22121<\/jats:sup>\n diet (\n p<\/jats:italic>\n \u00a0<\u00a00.05). Administration of 100\u00a0mg CoQ10\u00a0kg\n \u22121<\/jats:sup>\n diet significantly reduced the liver gene expression of sterol regulatory element\u2010binding protein1 (SREBP1), whereas supplementation with 200\u00a0mg CoQ10\u00a0kg\n \u22121<\/jats:sup>\n diet increased muscle gene expression of SREBP1 (\n p<\/jats:italic>\n \u00a0<\u00a00.05). However, there were negative associations and correlations between blood TGs and CHO levels with liver and muscle SREBP1 gene expression.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Overall, dietary supplementation of CoQ10, particularly at the levels of 100\u2013200\u00a0mg\u00a0kg\n \u22121<\/jats:sup>\n of diet, can improve growth performance and health in rainbow trout by modifying blood metabolites and SREBP1 gene expression.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/vms3.70324","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T14:18:15Z","timestamp":1744035495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Dietary Supplementation of Coenzyme Q10 on Growth Performance, Biochemical and Physiological Attributes of Rainbow Trout (\n Oncorhynchus mykiss<\/i>\n )"],"prefix":"10.1002","volume":"11","author":[{"given":"Hajar","family":"Asgari","sequence":"first","affiliation":[{"name":"Department of Animal Sciences Sh K.C., Islamic Azad University Shahr\u2010e Kord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-4776","authenticated-orcid":false,"given":"Sayed Mohammad Ali","family":"Jalali","sequence":"additional","affiliation":[{"name":"Research Center of Nutrition and Organic Products (RCNOP), Shahrekord Branch Islamic Azad University Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Faghani","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Sh K.C., Islamic Azad University Shahr\u2010e Kord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar","family":"Hematzadeh","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Sh K.C., Islamic Azad University Shahr\u2010e Kord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"147","article-title":"Effect of Vegetable Oil Source and L\u2010Carnitine Supplements on Growth Performance, Carcass Characteristics and Blood Biochemical Parameters of Japanese Quails (Coturnix japonica)","volume":"7","author":"Abedpour A.","year":"2017","journal-title":"Iranian Journal of Applied Animal Science"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jwas.13034"},{"key":"e_1_2_11_4_1","volume-title":"Official Methods of Analysis of AOAC International","author":"AOAC","year":"2005"},{"key":"e_1_2_11_5_1","first-page":"597","article-title":"Effects of Different Sources of Dietary\u2010Antioxidants (Vitamin E, Co\u2010Enzyme Q10 and Selenium Forms) on Growth Performance and Biochemical Indices in Rainbow Trout (Onchorhynchus mykiss) Fingerlings","volume":"74","author":"Aramli M. 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