{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:44:50Z","timestamp":1784763890969,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the prostate gland in adult male dogs, often resulting in significant clinical manifestations. Doppler ultrasonography offers a non\u2010invasive method to assess prostatic haemodynamics and vascular properties, which are crucial for understanding the pathophysiology of BPH and treatment effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of finasteride treatment on the haemodynamic and vascular properties of the canine prostate using B\u2010mode and Doppler ultrasonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixteen dogs of different breeds, body weights (20\u201343\u00a0kg) and ages (6\u201313 years) were used in the study and classified into a healthy control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08) and a BPH group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08). BPH presumptive diagnosis was performed through reproductive history, clinical signs (tenesmus, haematuria or dysuria) and prostatic volume by B\u2010mode ultrasonography. The BPH group received finasteride treatment for 2 months. Prostate volume (PV), peak systolic velocity (PSV), end\u2010diastolic velocity (EDV), resistive index (RI) and pulsatility index (PI) were measured before and after treatment using B\u2010mode and Doppler ultrasonography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The BPH group exhibited a significant reduction in PV from 25.10\u00a0\u00b1\u00a018.55\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      to 18.55\u00a0\u00b1\u00a04.18\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      post\u2010treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). PSV and EDV were significantly higher in the BPH group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) than in the healthy control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The BPH pre\u2010treatment group had higher RI and PI values than the post\u2010treatment group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Additionally, finasteride treatment led to a marked decrease in RI and PI values (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), bringing these parameters in line with those of healthy dogs. Enhanced blood flow parameters were observed, indicating the effectiveness of finasteride in reducing prostatic vascular resistance and improving overall prostate health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Finasteride treatment is effective in reducing PV and improving blood flow parameters in dogs with BPH. Doppler ultrasonography is a valuable tool for monitoring treatment response and assessing prostatic haemodynamics in canine BPH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70337","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T08:44:58Z","timestamp":1745311498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Doppler Ultrasonography in the Diagnosis of Dogs With Benign Prostatic Hyperplasia and Investigation of the Efficacy of Finasteride in Treatment"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5728-1478","authenticated-orcid":false,"given":"Burcu","family":"Esin","sequence":"first","affiliation":[{"name":"Department of Animal Reproduction and Artificial Insemination University of Ondokuz Mayis  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0666-5359","authenticated-orcid":false,"given":"Cumali","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction and Artificial Insemination University of Ondokuz Mayis  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-9066","authenticated-orcid":false,"given":"\u00c7a\u011fatay","family":"Esin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine University of Ondokuz Mayis  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.163.6.179"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201071691\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201071691\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234714"},{"key":"e_1_2_9_6_1","unstructured":"Angrimani D. 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