{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:42:34Z","timestamp":1777585354079,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coccidiosis is an important parasitic disease of broiler chickens. Drug resistance to the polyether polyether Ionophore anticoccidial drugs \u00a0(PACDs) caused by long\u2010term use has emerged as a significant problem in commercial broiler chicken production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study explored the feasibility of 1,8\u2010cineole (CIN) in replacing PACD with broiler feeding experiments and intestinal microecological experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This experiment selected 21\u2010day\u2010old Lingnan yellow (LNY) broilers and randomly divided them into 8 groups, with 30 chickens in each group. They were uniformly fed with full feed during the breeding period. The experimental groups were as follows: (i) three broiler groups that were fed a PACD supplementation (G1: Salinomycin Premix [SAP] 60\u00a0mg\/kg; G2: Monensin Premix [MOP] 100\u00a0mg\/kg and G3: Maduramicin Premix [MAP] 5\u00a0mg\/kg), (ii) three broiler groups that were administered different CIN dosages (G4: CIN\u2010L 100\u00a0mg\/kg, G5: CIN\u2010M 150\u00a0mg\/kg and G6: CIN\u2010H 250\u00a0mg\/kg) and (iii) two control broiler groups (G7: infected control group and G8: healthy control group). On the 23rd day, all groups were infected with coccidian cysts, except the G8 group which was used as a blank control. After 2 weeks of continuous feeding, the growth performance changes of broilers were analysed, and the intestinal lesions of eight groups of broilers were analysed after slaughter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with PACD treatment, the average daily feed intake (ADFI) of the three CIN\u2010treated groups increased by 13%, whereas the feed conversion ratio (FCR) reduced by 28%. FCR value for the high\u2010dose CIN treatment was 2.04, 34% decline which compared with control group infected with spore oocysts. The anticoccidial index (ACI) of all PACD treatments was less than 120, whereas the ACI of the middle\u2010 and high\u2010dose CIN treatments was higher than 180. In comparison to the\n                      <jats:italic>Eimeria<\/jats:italic>\n                      \u2010infected control group, the diversity and total number of the microbiota in the CIN treatments increased significantly. Moreover, CIN treatment favoured the proliferation of intestinal probiotics, especially\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      sp.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CIN could have an inhibitory effect on parasite development as suggested in the gene function annotation of the intestinal microbiota. These results demonstrate that CIN may be a feasible natural alternative to anticoccidiosis drugs. So it was important to take precautions against and control coccidiosis in poultry production which has a lesser risk of creating resistance to substitutive PACDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70341","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T05:44:06Z","timestamp":1745646246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Substituting Polyether Ionophore Anticoccidial Drugs With 1, 8\u2010Cineole for the Control of\n                    <i>Eimeria<\/i>\n                    Infections in Broilers"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-7525","authenticated-orcid":false,"given":"Jing","family":"Sun","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin The People's Republic of China"},{"name":"Tianjin Naer Biotechnology Co., LTD.  Tianjin The People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjun","family":"Bao","sequence":"additional","affiliation":[{"name":"Tianjin Naer Biotechnology Co., LTD.  Tianjin The People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Han","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin The People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Naer Biotechnology Co., LTD.  Tianjin The People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin The People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"100497","article-title":"Effects of Eucalyptus Globulus Leaves Powder on Growth Performance, Internal Organs Weights, Hematological and Biochemical Parameters of Isa Brown Pullets","volume":"4","author":"Aduayi A.","year":"2024","journal-title":"Journal of Applied Poultry Research"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.15.1.58\u201065.2002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962\u20104562(97)80020\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104894(70)90064\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079459708419208"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020\u20107519(98)00024\u20101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.10"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","unstructured":"Germana F. 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