{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:14:41Z","timestamp":1774271681619,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Palmatine is an isoquinoline alkaloid isolated from many medicinal plants with diverse pharmacological activities, with potential for the treatment of chronic metabolic disorders and infectious diseases. In the present study, a highly rapid, simple, and sensitive ultra\u2010performance liquid chromatography coupled with an ultra\u2010violet (\n                    <jats:bold>UPLC\u2010UV<\/jats:bold>\n                    ) method was developed and validated for the pharmacokinetics and tissue distribution of palmatine following single intramuscular injection to Partridge Shank chickens. The process was sensitive, with a lower limit of quantification and good linearity over the range of 0.005\u201010 \u00b5g\/mL for UPLC\u2010UV in all biological matrices. Following a single intramuscular dose of 5 mg\/kg b.w, palmatine was absorbed quickly and reached peak concentration (0.24 \u00b5g\/mL) at 0.19 h and was still present in plasma at 12 h with a concentration of 0.011 \u00b5g\/mL. The CL\/F and Vd\/F were 10.43 L\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 56.69 L\/kg, respectively. The\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    values of palmatine in tissues decreased as follows: kidneys &gt; liver &gt; spleen &gt; heart &gt; lung &gt; muscles, and were almost completely cleared from lungs 26 h after administration and were not detectable or significantly reduced in other tissues after 48 h. The results can provide a basis for exploring the therapeutic potential of palmatine and looking for new ways of wide clinical applications in poultry farming.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70416","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T13:39:46Z","timestamp":1750340386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics and Tissue Distribution of Palmatine after Single Intramuscular Injection in Partridge Shank Chickens"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6632-859X","authenticated-orcid":false,"given":"Chaoxi","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6135-5611","authenticated-orcid":false,"given":"Yue Bu Mo","family":"A\u2010ga","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhua","family":"Kuang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Henan University of Animal Husbandry and Economy  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Technology Center of Dalian Customs  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Institute of Animal Health, Guangdong Academy of Agricultural Sciences\/Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Zhengzhou Inspection and Testing Center of Product Quality  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600195-JLR200"},{"key":"e_1_2_9_3_1","first-page":"2","article-title":"The Effects of Berberine and Palmatine on Efflux Pumps Inhibition With Different Gene Patterns in Pseudomonas aeruginosa Isolated From Burn Infections","volume":"9","author":"Aghayan S.\u2010S.","year":"2017","journal-title":"Avicenna Journal of Medical 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