{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:31:55Z","timestamp":1792481515759,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hereditary diseases in cattle lead to economic losses across various breeds worldwide, with arachnomelia syndrome being one such disorder found in Simmental cattle. Arachnomelia results from a recessively inherited loss\u2010of\u2010function variant in the\n                    <jats:italic>MOCS1<\/jats:italic>\n                    gene detected only in Simmentals. In T\u00fcrkiye, prior research on hereditary cattle diseases has focused exclusively on dairy breeds, particularly Holstein. This study marks the first investigation in T\u00fcrkiye of a genetic disease in a dual\u2010purpose breed that is also valued for its beef traits. For this purpose, blood samples were collected from 387 Simmental cattle in Yozgat, T\u00fcrkiye. The variant\n                    <jats:italic>MOCS1<\/jats:italic>\n                    allele was analysed, and the results revealed four heterozygous samples carrying the causal two\u2010nucleotide frameshift deletion, as confirmed by Sanger sequencing. This research provides the first detection of arachnomelia in T\u00fcrkiye, with a prevalence of 1.03% heterozygous carriers in the population studied. To eliminate arachnomelia, screening of Simmental and Simmental\u2010cross cattle is recommended, with the avoidance of carrier matings to prevent the birth of affected calves.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70442","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T09:04:57Z","timestamp":1748855097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Detection of Arachnomelia Syndrome in Simmental Cattle in T\u00fcrkiye"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-6759","authenticated-orcid":false,"given":"Mehmet Cevat","family":"Temizkan","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine. Department of Genetics Yozgat Bozok University  Yozgat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4946-3749","authenticated-orcid":false,"given":"Gonca","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Genetics Selcuk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-0044","authenticated-orcid":false,"given":"Emre","family":"Sayar","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Internal Diseases Yozgat Bozok University  Yozgat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3906\/vet-1412-13"},{"key":"e_1_2_10_3_1","first-page":"127","article-title":"T\u00fcrkiye'deki Iki Farkl\u0131 I\u015fletmede Yeti\u015ftirilen Hol\u015ftayn Bo\u011falarda Fakt\u00f6r XI Yetmezli\u011fi (FXID) Allel Frekans\u0131n\u0131n Belirlenmesi","volume":"19","author":"Aky\u00fcz B.","year":"2013","journal-title":"Kafkas \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_10_4_1","first-page":"17","article-title":"T\u00fcrkiye'de Yeti\u015ftirilen Hol\u015ftayn Ve Baz\u0131 Yerli S\u0131\u011f\u0131r Irklar\u0131nda Citrullinemia Allelinin Belirlenmesi","volume":"5","author":"Aky\u00fcz B.","year":"2008","journal-title":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1501\/Vetfak_0000002223"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1556\/AVet.54.2006.2.4"},{"key":"e_1_2_10_7_1","first-page":"57","article-title":"T\u00fcrkiye'de Hol\u015ftayn Ve Yerli s\u0131\u011f\u0131rlarda \u00fcridin monofosfat sentetaz eksikli\u011finin (DUMPS) belirlenmesi","volume":"55","author":"Aky\u00fcz B.","year":"2008","journal-title":"Ankara \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_10_8_1","first-page":"519","article-title":"Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) Allele in Holstein Cows Reared in Kayseri Vicinity","volume":"16","author":"Aky\u00fcz B.","year":"2010","journal-title":"Kafkas \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_10_9_1","first-page":"31","article-title":"The Prevalence of BLAD and Comparison of Some Production Parameters in Carrier and Non\u2010Carrier Holstein Cows in Kayseri Province","volume":"12","author":"Aky\u00fcz B.","year":"2015","journal-title":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2017.18.4.465"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.30704\/http-www-jivs-net.324403"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2009.01933.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-4-39"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-12-11"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-017-0525-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.33988\/auvfd.436199"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001079"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.29136\/mediterranean.578015"},{"key":"e_1_2_10_19_1","first-page":"17","article-title":"Inherited Disorders of Cattle: A Selected Review","volume":"43","author":"Gentile A.","year":"2006","journal-title":"Slovenian Veterinary Research"},{"key":"e_1_2_10_20_1","first-page":"24","article-title":"Genetic Diseases in Cattle: A Review","volume":"2","author":"Gholap P. 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