{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:48:52Z","timestamp":1775209732583,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of locally applied Nigella sativa (NS) oil and Vitamin E (vit E) in a rat adhesion model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty\u2010six male Wistar rats (90 days old, 240 \u00b1 37\u00a0g)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Animals were assigned to three groups: control (sterile saline), NS oil (10\u00a0mg\/kg), and vit E (50\u00a0mg\/kg). After inducing intra\u2010abdominal adhesion, the treatments were administered intraperitoneally. On day 8, rats were euthanized, and adhesions were scored macroscopically. Levels of IL\u20106, TNF\u2010\u03b1, PGE2, TGF\u2010\u03b21, VEGF, IL\u201010 and IL\u20101\u03b2 were measured, and histopathological evaluation and Picro\u2010Sirius Red staining were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adhesion scores did not significantly differ between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.680). TNF\u2010\u03b1 levels were significantly higher in the control group compared to the vit E group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011), with no significant difference between the NS oil and vit E groups. PGE2 levels differed significantly between the NS oil and vit E groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.023). IL\u20101\u03b2, IL\u20106, IL\u201010, TGF\u2010\u03b21 and VEGF levels did not show significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Histopathology revealed reduced fibrosis and inflammation in the vit E group compared to NS oil (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Picro\u2010Sirius Red staining showed improved collagen maturation in the vit E group, followed by NS oil, with the control group exhibiting less mature collagen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both treatments showed efficacy, but vit E was superior in reducing inflammation and fibrosis and enhancing collagen maturation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70446","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T12:09:17Z","timestamp":1748779757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the Effectiveness of Nigella Sativa and Vitamin E in Preventing Intra\u2010abdominal Adhesions"],"prefix":"10.1002","volume":"11","author":[{"given":"Musa","family":"Ozekinci","sequence":"first","affiliation":[{"name":"Department of Traditional, Complementary and Integrative Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Koc","sequence":"additional","affiliation":[{"name":"Department of Traditional, Complementary and Integrative Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5890-8271","authenticated-orcid":false,"given":"Latif Emrah","family":"Yanmaz","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i41.4545"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12544"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12544"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2015.11681129"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"293","article-title":"Pathophysiology of Adhesions","volume":"109","author":"Butureanu S. 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