{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:33:20Z","timestamp":1792708400542,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fasciolosis is a neglected zoonotic parasitic disease caused by\n                    <jats:italic>Fasciola hepatica<\/jats:italic>\n                    and\n                    <jats:italic>Fasciola gigantica<\/jats:italic>\n                    . It is a serious public health and veterinary concern, with significant consequences for both human and livestock populations. An abattoir\u2010based cross\u2010sectional study was conducted from January to September 2023 at Gondar ELFORA Abattoir, Northwest Ethiopia, to assess haematobiochemical alterations and pathological lesions induced by fasciolosis in slaughtered cattle. The study included one hundred apparently healthy male local\u2010breed cattle, divided into two groups of fifty: one infected and one non\u2010infected. Cattle were selected using a purposive sampling technique. Infected cattle showed significantly lower mean values for haemoglobin (HGB), haematocrit (HCT), mean corpuscular volume (MCV), total erythrocyte count (TEC), lymphocytes, monocytes, total protein, albumin and glucose compared to non\u2010infected cattle. Conversely, they had higher mean values for mean corpuscular haemoglobin concentration (MCHC), total leukocyte count (TLC), neutrophils, eosinophils, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). Basophil levels were similar in both groups. Liver alterations observed in acute fasciolosis included hepatomegaly with rounded edges and the presence of juvenile flukes within the parenchyma, while in chronic fasciolosis, the liver appeared smaller and firm, with a corrugated capsule and dilated bile ducts containing twisted flukes. Microscopically, acute fasciolosis showed eosinophil infiltration, hemosiderin pigmentation and congestion around the central vein and sinusoids, whereas chronic fasciolosis showed fibrosis, bile duct proliferation, and metaplasia of epithelial cells from columnar to cuboidal. The observed findings indicate a severe hepatic and systemic disease process driven by parasitic infection, resulting in significant compromise of the cattle's health. Therefore, regular screening and effective deworming are essential to control bovine fasciolosis, especially in high\u2010risk abattoirs. Haematology and biochemical tests should be part of routine diagnosis for early detection and liver function assessment, while histopathology confirms the infection stage. Enhancing stakeholder awareness and training is vital and further research on seasonal patterns, risk factors and drug resistance is needed to improve control strategies.\n                  <\/jats:p>","DOI":"10.1002\/vms3.70461","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:59:52Z","timestamp":1750157992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Haematobiochemical Alterations and Pathological Lesions Induced by Fasciolosis in Slaughtered Cattle at Gondar ELFORA Abattoir, Northwest Ethiopia"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5926-5568","authenticated-orcid":false,"given":"Abraham Belete","family":"Temesgen","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadegegn","family":"Mitiku","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mastewal","family":"Birhan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-9028","authenticated-orcid":false,"given":"Mersha Chanie","family":"Kebede","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Yesuf","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muluken Yayeh","family":"Mekonnen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moges Maru","family":"Alemayehu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birhan Anagaw","family":"Malede","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdo Megra","family":"Geda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aregash Wendimu","family":"Tumebo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefale Ambachew","family":"Shiferaw","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedical Science College of Veterinary Medicine and Animals Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerihun Getie","family":"Wassie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedical Science College of Veterinary Medicine and Animals Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genetu Kassahun","family":"Berie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedical Science College of Veterinary Medicine and Animals Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bemrew Admassu","family":"Mengistu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedical Science College of Veterinary Medicine and Animals Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melaku Getahun","family":"Feleke","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacy Pharmaceutical analysis and quality assurance University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikadu","family":"Edenshaw","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacy Pharmaceutical analysis and quality assurance University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulusew Tesfaye","family":"Yitie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gashaw Enbiyale","family":"Kasse","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine College of Veterinary Medicine and Animal Sciences University of Gondar  Gondar 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