{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:31:32Z","timestamp":1781613092600,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine &amp;amp; Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to investigate the effect of meloxicam on the pharmacokinetics of cefquinome in experimental endotoxemic sheep. In addition, the MIC of cefquinome was determined against\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      ,\n                      <jats:italic>Pasteurella multocida<\/jats:italic>\n                      ,\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      , and\n                      <jats:italic>Mannheimia haemolytica<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was carried out on six sheep in three periods according to a longitudinal pharmacokinetic design. Cefquinome (2.5\u00a0mg\/kg, IV, CFQ) was administered in the first period, cefquinome+meloxicam (1\u00a0mg\/kg, IV, CFQ+MLX) in the second period, and lipopolysaccharide (20\u00a0\u00b5g\/kg, IV, LPS+CFQ+MLX)+meloxicam+cefquinome in the third period. Plasma cefquinome concentrations were assayed using HPLC\u2010UV, and pharmacokinetic data were calculated by a two\u2010compartment open model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following a single IV injection of cefquinome, the t\n                      <jats:sub>1\/2\u03b2<\/jats:sub>\n                      , V\n                      <jats:sub>dss<\/jats:sub>\n                      , and Cl\n                      <jats:sub>T<\/jats:sub>\n                      values were 1.12\u00a0h, 0.21 L\/kg, and 0.17 L\/h\/kg, respectively. The t\n                      <jats:sub>1\/2\u03b2<\/jats:sub>\n                      was prolonged from 1.12 to 2.79\u00a0h in the LPS+CFQ+MLX group. While V\n                      <jats:sub>dss<\/jats:sub>\n                      was increased (from 0.21 to 0.36 L\/kg) in the LPS+CFQ+MLX group, Cl\n                      <jats:sub>T<\/jats:sub>\n                      decreased (from 0.17 to 0.10 L\/h\/kg) in the CFQ+MLX and LPS+CFQ+MLX groups. The MICs of cefquinome were 0.031 to 0.063\u00a0\u00b5g\/mL for\n                      <jats:italic>E. coli, M. haemolytica<\/jats:italic>\n                      , and\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      and 0.016 to 1\u00a0\u00b5g\/mL for\n                      <jats:italic>P. multocida<\/jats:italic>\n                      . At a 12\u00a0h dosing interval, the CFQ, CFQ+MLX, and LPS+CFQ+MLX groups attained a T &gt; MIC ratio of 40% for bacteria with MIC values of \u2264 0.50, \u2264 1, and \u2264 1 \u00b5g\/mL, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate that combined administration of meloxicam alters the pharmacokinetics and therapeutic efficacy of cefquinome in experimental endotoxemic sheep.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/vms3.70462","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T11:27:39Z","timestamp":1756985259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Meloxicam on the Pharmacokinetics of Cefquinome in Endotoxemic Sheep"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-4229","authenticated-orcid":false,"given":"Muhittin","family":"Uslu","sequence":"first","affiliation":[{"name":"Department of Laboratory and Veterinary Health Sefaatli Vocational College University of Yozgat Bozok  Yozgat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-2510","authenticated-orcid":false,"given":"Orhan","family":"Corum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Hatay Mustafa Kemal  Hatay T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-7245","authenticated-orcid":false,"given":"Enver","family":"Yazar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Selcuk  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"1","article-title":"Pharmacokinetics Profile of Danofloxacin in Febrile Camels With E. 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